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2021 年第 5 期 第 16 卷

热毒宁注射液联合干扰素雾化吸入治疗手足口病的效果和安全性分析

Effects and safety of Reduning injection combined with interferon nebulization on the treatment of hand, foot and mouth disease

作者:孙子发高健陈必全

英文作者:Sun Zifa Gao Jian Chen Biquan

单位:安徽省儿童医院感染科,合肥230001

英文单位:Department of Infection Anhui Children′s Hospital Hefei 230001 China

关键词:手足口病;热毒宁注射液;干扰素;雾化治疗

英文关键词:Hand,footandmouthdisease;Reduninginjection;Interferon;Nebulizationtherapy

  • 摘要:
  • 目的 探讨热毒宁注射液联合干扰素雾化吸入治疗手足口病的效果和安全性。方法 选取2019112月安徽省儿童医院收治的80例手足口病患儿,按随机数字表法分为对照组和观察组,各40例。对照组在常规对症支持治疗基础上口服利巴韦林治疗;观察组在常规对症支持治疗基础上采用热毒宁注射液联合注射用重组人干扰素α1b雾化吸入治疗。比较2组临床疗效,各项临床症状恢复时间和住院时间,治疗前后白细胞计数、C反应蛋白(CRP)、心肌酶谱、丙氨酸转氨酶(ALT)水平变化情况和不良反应发生情况。结果 观察组治疗后总有效率明显高于对照组[95.0%(38/40)75.0%(30/40)],差异有统计学意义(P=0.012)。观察组患儿体温恢复时间、口腔溃疡消失时间、手足疱疹康复时间及住院时间均明显短于对照组[(4.4±0.7d比(6.6±0.9d、(2.4±0.3d比(3.3±0.2d、(2.3±0.2d比(2.9±0.3d、(2.2±0.2d比(3.3±0.4d],差异均有统计学意义(均P0.001)。治疗后,观察组患儿白细胞计数、CRP、心肌酶谱各指标及ALT水平均明显低于对照组(均P0.05)。2组患儿治疗期间不良反应发生率比较差异无统计学意义(P=0.456)。结论 热毒宁注射液联合干扰素雾化吸入治疗手足口病患儿能够取得较为理想的治疗效果,有利于缩短患儿症状消退时间和住院时间,同时安全性较好。

  • Objective To investigate the effects and safety of Reduning injection combined with interferon nebulization on the treatment of hand, foot and mouth disease(HFMD). Methods From January to December 2019, 80 children with HFMD admitted to Anhui Childrens Hospital were selected. They were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with ribavirin orally on the basis of conventional symptomatic support treatment; the observation group was treated with Reduning injection combined with recombinant human interferon α 1b for injection nebulization on the basis of conventional symptomatic support treatment. The clinical effect, recovery time of clinical symptoms, length of stay, and white blood cell count, C-reactive protein (CRP), myocardial enzyme spectrum, alanine aminotransferase (ALT) levels before and after treatment and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group95.0%(38/40) vs 75.0%(30/40)(P=0.012). The recovery time of temperature, disappearance time of oral ulcer, recovery time of hand and foot herpes, and length of stay of the observation group were significantly shorter than those of the control group[(4.4±0.7d vs 6.6±0.9d, 2.4±0.3d vs 3.3±0.2d, 2.3±0.2d vs 2.9±0.3d, 2.2±0.2d vs 3.3±0.4d(all P0.001). After treatment, the white blood cell count, CRP, myocardial enzyme spectrum indexes and ALT levels of the observation group were significantly lower than those of the control group (all P0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P=0.456). Conclusion Reduning injection combined with interferon nebulization can achieve ideally therapeutic effect in children with HFMD, which is conducive to shorten the time of symptom regression and length of stay, and has good safety.

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