2021 年第 3 期 第 16 卷

沙库巴曲缬沙坦治疗心力衰竭的研究进展

Research progress of sacubitril/valsartan in the treatment of heart failure

作者：姜小霞赵翠萍

英文作者：Jiang Xiaoxia Zhao Cuiping

单位：哈尔滨医科大学附属第一医院心血管内科150000

英文单位：Department of Cardiovascular Medicine the First Affiliated Hospital of Harbin Medical University Harbin 150000 China

关键词：心力衰竭；沙库巴曲缬沙坦；血管紧张素Ⅱ受体拮抗剂；脑啡肽酶抑制剂

英文关键词：Heartfailure；Sacubitril/valsartan；AngiotensinⅡreceptorblocker；Neprilysininhibitor

• 摘要：

• 心力衰竭是现代心血管疾病的终末阶段，其患病率和长期死亡率居高不下，给患者带来了极其严重的负担。沙库巴曲缬沙坦现已成为治疗心力衰竭的基石，得到了临床医师的极大认可。本文对沙库巴曲缬沙坦的药物作用机制、药代动力学和药效动力学、对心力衰竭的相关临床研究及其他附加作用进行综述。

• Heart failure is the terminal stage of modern cardiovascular disease. Its prevalence and long-term mortality rate remain high, which brings an extremely severe burden to patients. Sacubitril/valsartan is now the cornerstone of the treatment in heart failure. It has been greatly recognized by clinicians. This paper summarizes the drug mechanism, pharmacokinetic, pharmacodynamics, related clinical studies on heart failure and other additional effects of sacubitril/valsartan.