2021 年第 3 期 第 16 卷

阿立哌唑治疗儿童注意缺陷多动障碍合并破坏性行为障碍的效果及对炎症因子水平的影响

Effect of aripiprazole on children with attention deficit hyperactivity disorder combined with disruptive behavior disorder and its influence on inflammatory factors levels

作者：王勇1王臻颉2

英文作者：Wang Yong1 Wang Zhenjie2

单位：1湖北省黄冈市中医医院儿科438000；2湖北省黄冈市中医医院骨科438000

英文单位：1Department of Pediatrics Huanggang Hospital of Traditional Chinese Medicine Hubei Province Huanggang 438000 China; 2Department of Orthopaedics Huanggang Hospital of Traditional Chinese Medicine Hubei Province Huanggang 438000 China

关键词：

英文关键词：Attentiondeficithyperactivitydisorder;Disruptivebehaviordisorder;Aripiprazole;Inflammatoryfactors

• 摘要：

• 目的 观察阿立哌唑治疗儿童注意缺陷多动障碍（ADHD）合并破坏性行为障碍的效果及对炎症因子水平的影响。方法 选取2016年1月至2018年1月湖北省黄冈市中医医院门诊和病房诊治的120例ADHD合并破坏性行为障碍患儿为研究对象。给予阿立哌唑治疗6周，采用Conner′s父母用症状问卷于治疗前和治疗1、2、4、6周后进行疗效评价，比较治疗前及治疗2、6周后血清炎症因子水平变化。结果 阿立哌唑治疗前及治疗1、2、4、6周后比较发现，患儿Conner′s父母用症状问卷品行问题、学习问题、心身障碍、冲动-多动及焦虑评分随治疗时间的延长逐步降低，两两时点比较差异均有统计学意义（均P<0.05）。治疗6周后总有效率高于治疗2周后［83.3%（100/120）比63.3%（76/120）］，差异有统计学意义（χ2=15.518，P=0.004）。治疗2、6周后患儿白细胞介素1β（IL-1β）、IL-2及IL-6水平较治疗前明显降低，且治疗6周后低于治疗2周后，差异均有统计学意义（均P<0.05）。结论 阿立哌唑能有效治疗儿童ADHD合并破坏性行为障碍，且可降低患儿血清炎症因子水平。

• Objective To observe the effect of aripiprazole on children with attention deficit hyperactivity disorder (ADHD) combined with disruptive behavior disorder（DBD） and its influence on inflammatory factors levels. Methods Totally 120 children with ADHD combined with DBD were selected from the outpatient and ward of Huanggang Hospital of Traditional Chinese Medicine， Hubei Province from January 2016 to January 2018. Aripiprazole was given for 6 weeks. Conner′s parents symptom questionnaire was used to evaluate the curative effect before and after 1, 2, 4, 6 weeks of treatment, and the changes of serum inflammatory factors before and after 2 and 6 weeks of treatment were compared. Results Before and after 1, 2, 4 and 6 weeks of aripiprazole treatment, the scores of behavior problems, learning problems, psychosomatic disorders, impulsive hyperactivity and anxiety scores of the children′s Conner′s parents symoptom questionnaire gradually decreased with the extension of treatment time, and the differences were statistically significant between every two time points (all P<0.05). The total effective rate after 6 weeks of treatment was higher than that after 2 weeks of treatment［83.3%(100/120) vs 63.3%(76/120)］ (χ2=15.518, P=0.004). After 2 and 6 weeks of treatment, the levels of interleukin (IL)-1β, IL-2 and IL-6 were significantly lower than those before treatment, and those after 6 weeks of treatment were lower than those after 2 weeks of treatment (all P<0.05). Conclusion Aripiprazole is effective in treatment of children with ADHD and DBD, and can reduce serum inflammatory factor levels.