2021 年第 3 期 第 16 卷

沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺疾病的临床效果

The clinical effect of salbutamol combined with budesonide atomization for inhalation on  chronic obstructive pulmonary disease

作者：邵宁陶丽丽

英文作者：Shao Ning Tao Lili

单位：中国人民解放军联勤保障部队第九〇四医院药剂科，江苏省无锡市214044

英文单位：Department of Pharmacy the 904th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army Jiangsu Province Wuxi 214044 China

关键词：慢性阻塞性肺疾病；沙丁胺醇；布地奈德；雾化

英文关键词：Chronicobstructivepulmonarydisease;Salbutamol;Budesonide;Atomization

• 摘要：

• 目的 探讨沙丁胺醇联合布地奈德雾化吸入治疗慢性阻塞性肺疾病（COPD）的临床效果。方法 选取2017年5月至2019年4月因COPD来中国人民解放军联勤保障部队第九〇四医院住院治疗的患者120例。按照随机数字表法分为对照组和观察组，各60例。对照组患者在常规治疗基础上给予沙丁胺醇雾化吸入治疗，2次/d，每次15 min；观察组患者在常规治疗基础上给予沙丁胺醇联合布地奈德雾化吸入治疗，2次/d，每次15 min；2组患者均治疗1周。1周后观察2组患者的临床疗效、肺功能指标、血气指标和不良反应发生情况。结果 观察组总有效率明显高于对照组［91.7%（55/60）比75.0%（45/60）］，差异有统计学意义（χ2=8.84，P=0.01）。治疗后，2组第1秒用力呼气容积、第1秒用力呼气容积占用力肺活量百分比、最大呼气流量、25%肺活量的最大呼气流量均较治疗前升高，且观察组均高于对照组，差异均有统计学意义（均P<0.05）。治疗后，2组动脉血氧分压均较治疗前升高，且观察组高于对照组，动脉血二氧化碳分压均较治疗前降低，且观察组低于对照组，差异均有统计学意义（均P<0.05）。观察组不良反应总发生率低于对照组［5.0%（3/60）比16.7%（10/60）］，差异有统计学意义（χ2=4.22，P=0.04）。结论 布地奈德和沙丁胺醇联合治疗COPD有较好的治疗效果，且不良反应发生率低。

• Objective To explore the clinical effect of salbutamol combined with budesonide atomization for inhalation on chronic obstructive pulmonary disease(COPD). Methods From May 2017 to April 2019， 120  COPD patients admitted to the 904th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army  were selected. They were randomly divided into control group and observation group, with 60 cases in each group. The patients in control group were given atomization for inhalation of salbutamol on the basis of conventional treatment, 2 times/d, 15 min each time. The patients in observation group were given atomization for inhalation of salbutamol combined with budesonide on the basis of conventional treatment, 2 times/d, 15 min each time. Both groups were treated for 1 week. After 1 week treatment, clinical efficacy, lung function indexes, blood gas indexes and adverse reactions of the two groups were observed. Results The total effective rate of the observation group was significantly higher than that of the control group［91.7%(55/60) vs 75.0%(45/60)］(χ2=8.84, P=0.01). After treatment, the forced expiratory volume in the first second, the percentage of forced expiratory volume in the first second/forced vital capacity, the maximum expiratory flow and the maximum expiratory flow of 25% vital capacity in the two groups increased compared with those before treatment, and those in the observation group were higher than those in the control group, and the differences were statistically significant （all P<0.05）. After treatment, the arterial blood oxygen partial pressure of the two groups were higher than those before treatment, and that of the observation group was higher than that of the control group; the arterial blood carbon dioxide partial pressure of the two groups were lower than those before treatment, and that of the observation group was lower than that of the control group, and the differences were statistically significant(all P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group［5.0%(3/60) vs 16.7%(10/60)］(χ2=4.22, P=0.04). Conclusion The combination of budesonide and salbutamol has good therapeutic effect on COPD, and the incidence of adverse reactions is low.