2020 年第 10 期 第 15 卷

钙激活蛋白在镍接触肺腺癌患者和矽肺患者血清中的表达情况研究

Expression of calcium-activated protein-43 in patients with Ni-exposed lung adenocarcinoma and silicosis

作者：庞波1董明霞1李娟1邱镞文1胡高林1李茜1胡卓君1徐俊2

英文作者：Pang Bo1 Dong Mingxia1 Li Juan1 Qiu Zuwen1 Hu Gaolin1 Li Xi1 Hu Zhuojun1 Xu Jun2

单位：1四川省攀枝花市第二人民医院职业病科617068；2四川省南充市中心医院肿瘤科637000

英文单位：1Department of Occupational Medicine the Second People′s Hospital of Panzhihua Sichuan Province Panzhihua 617068 China; 2Department of Oncology Nanchong Central Hospital Sichuan Province Nanchong 637000 China

关键词：肺腺癌；钙激活蛋白；镍钛接触；矽肺

英文关键词：Lungadenocarcinoma;Calcium-activatedprotein;NiTi-exposed;Silicosis

• 摘要：

• 目的 探究镍接触肺腺癌患者和矽肺患者血清中钙激活蛋白（Cap43）的表达情况。方法研究对象为四川省攀枝花市第二人民医院2015年2月至2018年2月收治的17例镍接触肺腺癌患者、26例镍接触矽肺患者，以及同期28例镍接触工人、25例正常人，采集血清通过酶联免疫吸附试验法检测不同人群中Cap43的表达。结果 正常人群、镍接触工人、镍接触矽肺患者及镍接触肺腺癌患者之间，血清Cap43表达呈上升趋势［（0.263±0.022）、（0.571±0.051）、（0.894±0.082）、（1.996±0.137）μg/L］，两两比较差异均有统计学意义（均P＜0.01）。结论 血清Cap43表达有助于鉴别镍接触人群肺腺癌、矽肺情况，辅助临床确诊治疗。

• Objective To explore the expression of calcium-activated protein-43(Cap43) in Ni-exposed lung adenocarcinoma patients and silicosis patients. Methods From February 2015 to February 2018, 17 patients with Ni-exposed lung adenocarcinoma, 26 patients with Ni-exposed silicosis, 28 Ni-exposed workers and 25 healthy people were tested serum Cap43 by enzyme-linked immunosorbent assay. Results There were significant differences of Cap43 expression among healthy people, Ni-exposed workers, Ni-exposed silicosis patients and Ni-exposed lung adenocarcinoma patients［（0.263±0.022）,（0.571±0.051）,（0.894±0.082）,（1.996±0.137）μg/L］（all P＜0.01）. Conclusion Detection of serum Cap43 can help to identify the diagnosis between adenocarcinoma and silicosis.