2020 年第 11 期 第 15 卷

硝苯地平联合硫酸镁治疗妊娠高血压的效果及对患者血清同型半胱氨酸和胱抑素C水平的影响

Effect of nifedipine combined with magnesium sulfate on gestational hypertension, homocysteine and cystatin C levels 

作者：杨小蕾李宗婷陈桂林

英文作者：Yang Xiaolei Li Zongting Chen Guilin 

单位：江苏省连云港市第二人民医院妇产科222000 

英文单位：Department of Obstetrics and Gynecology Lianyungang Second People′s Hospital Jiangsu Province Lianyungang 222000 China

关键词：妊娠高血压；硝苯地平；硫酸镁；同型半胱氨酸；胱抑素

英文关键词：Gestationalhypertension;Nifedipine;Magnesiumsulfate;Homocysteine;CystatinC

• 摘要：

• 目的 观察硝苯地平联合硫酸镁治疗妊娠高血压的效果及对患者血清同型半胱氨酸（Hcy）和胱抑素C水平的影响。方法 回顾性分析2013年1月至2017年6月江苏省连云港市第二人民医院收治的120例妊娠高血压患者的临床资料。按治疗方式不同分为对照组（55例）和观察组（65例），对照组采用拉贝洛尔联合硫酸镁治疗，观察组采用硝苯地平联合硫酸镁治疗，2组均治疗7 d。比较2组研究对象的治疗效果及治疗前后血清Hcy及胱抑素C水平变化。结果 治疗后2组收缩压、舒张压均较治疗前降低，且观察组低于对照组［（126±15）mmHg（1 mmHg=0.133 kPa）比（135±14）mmHg、（81±8）mmHg比（94±8）mmHg］，差异均有统计学意义（均P<0.05）。治疗后，2组子宫动脉搏动指数、阻力指数、收缩期峰值流速与舒张末期流速比值均较治疗前降低，且观察组低于对照组，收缩期最大流速、舒张期最小流速均较治疗前增高，且观察组高于对照组，差异均有统计学意义（均P<0.05）。治疗后2组血清Hcy、胱抑素C水平均较治疗前降低，且观察组低于对照组［（10.2±2.9）μmol/L比（20.5±3.9）μmol/L、（0.95±0.12）mg/L比（1.65±0.30）mg/L］，差异均有统计学意义（均P<0.05）。结论 硝苯地平联合硫酸镁治疗妊娠高血压有较好的效果，且可显著降低患者血清胱抑素C及Hcy水平。

• Objective To observe the effect of nifedipine combined with magnesium sulfate on gestational hypertension, and its influence on homocysteine (Hcy) and cystatin C levels. Methods The clinical data of 120 cases of gestational hypertension admitted to Lianyungang Second People′s Hospital, Jiangsu Province from January 2013 to June 2017 were analyzed. They were divided into control group (55 cases) and observation group (65 cases) according to the treatment method. Control group was treated by magnesium sulfate combined labetalol and observation group were treated by nifedipine combined with magnesium sulfate; both groups were treated for 7 days. The therapeutic effects of two groups were analyzed; the changes of serum Hcy and cystatin C levels before and after treatment were analyzed. Results After treatment, the systolic and diastolic blood pressure of the two groups were lower than those before treatment; they were lower in observation group than in control group［（126±15）mmHg vs （135±14）mmHg, （81±8）mmHg vs （94±8）mmHg］(all P<0.05). After treatment, the pulsation index, resistance index, the ratio of peak systolic velocity to end diastolic velocity of uterine artery in the two groups were lower than those before treatment; those were lower in observation group than in control group; the maximum systolic velocity and the minimum diastolic velocity after treatment were higher than those before treatment (all P<0.05). After treatment, the levels of Hcy and cystatin C in the two groups were lower than those before treatment; those were lower in observation group than in control group［（10.2±2.9）μmol/L vs （20.5±3.9）μmol/L, （0.95±0.12）mg/L vs （1.65±0.30）mg/L］; the differences were statistically significant(all P<0.05). ConclusionNifedipine combined with magnesium sulfate shows a good effect on gestational hypertension; this therapy can significantly reduce the levels of Hcy and cystatin C.