2020 年第 7 期 第 15 卷

血液中提示颅内动脉瘤形成的潜在标志物研究进展 

Research progress of potential blood markers of intracranial aneurysm 

作者：杨亚莲1张赛2涂悦2张婷3王振国2吴焕成4刘洋5

英文作者：Yang Yalian1 Zhang Sai2 Tu Yue2 Zhang Ting3 Wang Zhenguo2 Wu Huancheng4 Liu Yang5

单位：1中国人民武装警察部队特色医学中心急诊医学科，天津300162；2中国人民武装警察部队特色医学中心脑科中心，天津300162；3中国人民武装警察部队后勤学院研究生大队，天津300162；4天津市北辰医院脑系科300400；5上海市闵行区中心医院神经内科201199

英文单位：1Department of Emergency Characteristic Medical Center of Chinese People′s Armed Police Forces Tianjin 300162 China； 2Brain Center Characteristic Medical Center of Chinese People′s Armed Police Forces Tianjin 300162 China； 3the Graduatede Regiment of Logistics College of Chinese People′s Armed Police Forces Tianjin 300162 China； 4Department of Brain Tianjin Beichen Hospital Tianjin 300400 China； 5Department of Neurology the Minhang Central Hospital of Shanghai Shanghai 201199 China

关键词：颅内动脉瘤；生物标志物；炎症；内皮祖细胞；胱抑素C；微小核糖核酸

英文关键词：Intracranialaneurysm；Biomarker；Inflammation；Endothelialprogenitorcells；CystatinC；MicroRNA-latin;mso-bidi-font-family:"TimesNewRoman";mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN;mso-bidi-language:AR-SA'>sArmedPoliceForces,Tianjin300162,China；4DepartmentofBrain,TianjinBeichenHospital,Tianjin300400,China；5DepartmentofNeurology,theMinhangCentralHospitalofShanghai,Shanghai201199,China

• 摘要：

• 颅内动脉瘤（IA）的形成是一个相对复杂而长期的过程，这期间一旦发生破裂引起蛛网膜下腔出血，就会严重危及患者生命。但绝大多数患者患病期间无自觉症状，使其很难被发现，而筛查手段又较为昂贵，难以普及。若能从血液中寻找一种便于检测的生物标志物用来提示IA的发生，对于预防脑卒中具有重要意义。为此本文对血液中可能提示IA形成的潜在标志物进行综述，为疾病的预防与治疗提供一定参考。

• The formation of intracranial aneurysm(IA) is a long-term process, during which subarachnoid hemorrhage caused by rupture may seriously affect patientlife. Most patients with IA are difficult to notice due to the lack of conscious symptoms.Common screening methods are expensive. It is of great significance to find easy-to-use biomarkers of IA. Early detection and effective intervention of IA can reduce the risk of cerebral apoplexy. This paper reviewed the progress of potential biomarkers of IA.