2020 年第 7 期 第 15 卷

冠状动脉慢血流的相关危险因素分析

Risk factors of coronary slow flow

作者：赵子威杨杰刘妍朱小刚高雅楠闫振娴刘晓丽周玉杰

英文作者：Zhao Ziwei Yang Jie Liu Yan Zhu Xiaogang Gao Yanan Yan Zhenxian Liu Xiaoli Zhou Yujie

单位：首都医科大学附属北京安贞医院心内十二病房北京市心肺血管疾病研究所冠心病精准治疗北京市重点实验室首都医科大学冠心病临床诊疗与研究中心100029 

英文单位：The 12th Ward Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Heart Disease Clinical Center for Coronary Heart Disease Capital Medical University Beijing 100029 China

关键词：冠状动脉慢血流；冠状动脉造影；冠状动脉疾病；危险因素

英文关键词：Coronaryslowflow;Coronaryangiography;Coronaryarterydisease;Riskfactors

• 摘要：

• 目的探讨冠状动脉慢血流（CSF）现象发生的危险因素。方法根据校正的心肌梗死溶栓实验血流计帧法，回顾性选取2009年1月至2017年6月在首都医科大学附属北京安贞医院行冠状动脉造影并诊断CSF患者429例（CSF组），以同时期432例冠状动脉血流正常患者作为对照组，研究2组患者临床资料、病史及辅助检查结果，并进行多因素Logistic回归分析。结果2组患者的性别、年龄、吸烟比例、饮酒比例、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、同型半胱氨酸、白细胞计数、红细胞计数、血小板计数、血红蛋白水平、血细胞比容、红细胞体积分布宽度、总胆红素、直接胆红素、中性粒细胞计数、嗜酸性粒细胞和嗜碱性粒细胞计数差异均有统计学意义（均P＜0.05)。多因素Logistic回归分析结果表明，男性（比值比＝1.606，95%置信区间1.060～2.435，P＝0.026）、吸烟（比值比＝1.669，95%置信区间1.145～2.433，P＝0.008）和红细胞计数增高（比值比＝2.039，95%置信区间1.378～3.017，P＜0.001）为CSF的独立危险因素。结论男性、吸烟史、红细胞增多为CSF的独立危险因素。

• ObjectiveTo investigate the risk factors of coronary slow flow (CSF) phenomenon. Methods From January 2009 to June 2017， 429 cases diagnosed as CSF by coronary angiography admitted to Beijing Anzhen Hospital, Capital Medical University were selected as CSF group， 432 patients with normal coronary blood flow in the same period were selected as the control group.The clinical data, medical history and auxiliary examination results   of the two groups were compared, and multivariate logistic regression analysis was performed. Results  There were statistically significant between two groups  in sex, age, smoking ratio, alcohol consumption ratio, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, homocysteine, white blood cell count, red blood cell count, platelet count, hemoglobin level, hematocrit , Width of red blood cell volume distribution, total bilirubin, direct bilirubin neutrophil count, eosinophil and basophil count（all  P＜0.05）, Multivariate logistic regression analysis showed that male［odds ratio(OR)=1.606, 95% confidence interval(CI) 1.060-2.435, P=0.026］, smoking(OR=1.669, 95% CI 1.145-2.433, P=0.008), and increased red blood cell counts (OR=2.039, 95% CI 1.378-3.017, P＜0.001)were independent risk factors for the occurrence of CSF. Conclusion Male, smoke and increased red blood cell are the independent risk factors of CSF.