2020 年第 8 期 第 15 卷

左氧氟沙星联合坦索罗辛治疗慢性前列腺炎的临床效果

Clinical effect of levofloxacin combined with tamsulosin in the treatment of chronic prostatitis

作者：姚泽钦陈国强汪溢朱家利霍振清罗后宙梁冰

英文作者：Yao Zeqin Chen Guoqiang Wang Yi Zhu Jiali Huo Zhenqing Luo Houzhou Liang Bing

单位：海南省三亚中心医院海南省第三人民医院泌尿外科572000

英文单位：Department of Urology Surgery Sanya Central Hospital the Third People′s Hospital of Hainan Province Hainan Province Sanya 572000 China

关键词：慢性前列腺炎；坦索罗辛；尿动力学；生活质量 

英文关键词：Chronicprostatitis;Tamsulosin;Urodynamics;Qualityoflife 

• 摘要：

• 目的 探讨左氧氟沙星联合坦索罗辛治疗慢性前列腺炎的临床效果。方法 选取2017年2月至2019年2月海南省三亚中心医院收治的慢性前列腺炎患者130例，应用随机数字表法分为2组，对照组63例，给予左氧氟沙星胶囊口服；观察组67例，在对照组治疗的基础上联合盐酸坦索罗辛缓释胶囊口服治疗。2组均治疗3个月，比较2组患者治疗3个月后的临床疗效，以及治疗前后2组患者前列腺液白细胞计数、分泌型免疫球蛋白A、白细胞介素8水平和尿动力学指标、生活质量评分。结果 治疗3个月后,观察组临床疗效优于对照组，治疗总有效率高于对照组［85.1%(57/67)比65.1%（41/63）］（均P＜0.05）。治疗3个月后，2组患者前列腺液白细胞计数及分泌型免疫球蛋白A、白细胞介素8水平和残余尿量均低于治疗前，且观察组显著低于对照组［(13.3±3.3)个/HP比（19.9±2.8）个/HP、(50±17)g/L比（98±17）g/L、(5.4±1.1)μg/L比（8.2±1.4）μg/L、(6.0±1.1)ml比（11.1±1.5）ml］,最大尿流率和生活质量评分均高于治疗前，且观察组显著高于对照组［(19.2±2.5)ml/s比（15.5±2.2）ml/s、(52±4)分比（44±5）分］(均P＜0.05）。结论 左氧氟沙星联合坦索罗辛治疗慢性前列腺炎，可明显改善患者尿动力学及生活质量，为慢性前列腺炎的临床治疗提供了理论依据。

• Objective To explore the clinical effect of levofloxacin combined with tamsulosin in the treatment of chronic prostatitis. Methods Totally 130 patients with chronic prostatitis treated in Sanya Central Hospital of Hainan Province from February 2017 to February 2019 were selected. The patients were divided into control group（63 cases） and observation group（67 cases） according to random number table. Control group were treated with levofloxacin capsule, observation group were treated with tamsulosin hydrochloride sustained-release capsule on the basis of the control group， both groups were treated for 3 months. After 3 months of treatment, the clinical efficacy was compared between the two groups. The prostatic fluid leukocyte count, secreted immunoglobulin A（sIgA）, interleukin-8 （IL-8）, urodynamic indexes, and quality of life scores were compared between the two groups before and after treatment. Results After 3 months of treatment, the clinical efficacy and the total effective rate of the treatment in observation group were higher than thoese in control group ［85.1%(57/67) vs 65.1%(41/63)］(both P<0.05). After 3 months of treatment, the leukocyte count, the level of slgA, IL-8 and the residual urine volume in the prostatic fluid of the two groups were lower than those before treatment, and those in observation group were significantly lower than thoese in control group ［(13.3±3.3)/HP vs (19.9±2.8)/HP, (50±17)g/L vs (98±17)g/L, (5.4±1.1)μg/L vs (8.2±1.4)μg/L, (6.0±1.1)ml vs (11.1±1.5)ml］, the maximum urine flow rate and quality of life scores in observation group were significantly higher than those in control group ［(19.2±2.5)ml/s vs (15.5±2.2)ml/s, (52±4) vs (44±5)， all P<0.05］. Conclusion Tamsulosin combined with levofloxacin can significantly improve the urodynamics and quality of life of patients with chronic prostatitis, which provides theoretical basis for the clinical treatment of chronic prostatitis.