2020 年第 8 期 第 15 卷

槐杞黄颗粒辅助吸入用布地奈德混悬液对重症肺炎支原体肺炎患儿肺功能和体液免疫功能的影响

Effect of Huaiqihuang granules assisted with budesonide suspension for inhalation on lung function and humoral immune fuction in children with severe mycoplasma pneumoniae pneumonia 

作者：卢旭常静张雪

英文作者：Lu Xu Chang Jing Zhang Xue

单位：陕西省安康市中心医院儿科725000

英文单位：Department of Pediatrics Ankang Central Hospital Shaanxi Province Ankang 725000 China

关键词：肺炎支原体肺炎；槐杞黄颗粒；吸入用布地奈德混悬液；肺功能；体液免疫

英文关键词：Mycoplasmapneumoniaepneumonia;Huaiqihuanggranules;Budesonidesuspensionforinhalation;Lungfunction;Humoralimmune

• 摘要：

• 目的 探讨槐杞黄颗粒辅助吸入用布地奈德混悬液对重症肺炎支原体肺炎（MPP）患儿肺功能和体液免疫功能的影响。方法 选择2017年1月到2019年5月陕西省安康市中心医院收治的重症MPP患儿105例，依照随机数字表法分为对照组（52例）和观察组（53例）。在常规治疗的基础上，对照组给予吸入用布地奈德混悬液治疗，观察组给予槐杞黄颗粒辅助吸入用布地奈德混悬液治疗。比较2组啰音消失时间、发热消失时间、咳嗽消失时间及住院时间。比较2组治疗前后的肺功能和体液免疫功能指标以及治疗1个月内的呼吸道感染再发生率。记录2组治疗过程中不良反应的发生情况。结果 观察组临床总有效率明显高于对照组［92.5%（49/53）比73.1%（38/52）］，差异有统计学意义（χ2=6.937，P=0.008）。观察组啰音消失时间、发热消失时间、咳嗽消失时间及住院时间均短于对照组，差异均有统计学意义（均P<0.001）。2组治疗后的第1秒用力呼气容积占预计值百分比、第1秒用力呼气容积与用力肺活量比值、最大呼气流量及免疫球蛋白A（IgA）、IgG、IgM水平均明显高于治疗前，且观察组高于对照组，差异均有统计学意义（均P<0.01）。观察组治疗1个月内的呼吸道感染再发生率低于对照组，差异有统计学意义（χ2=4.456，P=0.035）。治疗期间，2组均未发生严重的不良反应。结论 槐杞黄颗粒辅助吸入用布地奈德混悬液治疗重症MPP患儿的临床效果显著，能够明显改善肺功能，提高机体体液免疫功能，降低治疗期内患儿再次呼吸道感染发生率，且安全性较好。

• Objective To explore effect of Huaiqihuang granules assisted with budesonide suspension for inhalation on lung function and humoral immune fuction in children with severe mycoplasma pneumoniae pneumonia(MPP). Methods Totally 105 children with severe MPP admitted to Ankang Central Hospital, Shaanxi Province, from January 2017 to May 2019 were selected. They were randomized into the control group(52 cases) and the observasion group(53 cases). On the basis of routine treatment, patients in the control group were treated with budesonide suspension for inhalation, and patients in the observasion group were treated with Huaiqihuang granules assisted with budesonide suspension for inhalation. The disappearance time of rale, fever disappearance time, cough disappearance time and hospital stay time of the two groups were compared. The lung function and humoral immune function of the two groups before and after treatment were compared. The reoccurrence of respiratory tract infection and adverse reaction in one month after treatment of the two groups were compared. Results The total clinical effective rate of observation group was significantly higher than that of  control group［92.5%（49/53） vs 73.1%（38/52），χ2=6.937, P=0.008］. The disappearance time of rale, fever disappearance time, cough disappearance time and hospital stay time in observasion group were significantly shorter than those in control group(all P＜0.001). After treatment, forced expiratory volume in the first second as a percentage of the predicted value and the ratio of forced expiratory volume in the first second to forced vital capacity, peak expiratory flow and immunoglobulin A, immunoglobulin G, immunoglobulin M were significantly higher than those before treatment; the outcomes of observation group were significantly better than those of control group（all P＜0.01）. The reoccurrence of respiratory tract infection at 1 month after treatment in  observasion group was significantly lower than that in control group; the difference was statistically significant (χ2=4.456, P=0.035). During treatment, there were no adverse reactions in the two groups. Conclusion Huaiqihuang granule combined with budesonide suspension for inhalation in the treatment of children with severe MPP has significant clinical efficacy to improve lung and humoralimmune function, and reduce the reoccurrence of respiratory tract infection in children during the treatment period with a good safety.