2020 年第 4 期 第 15 卷

补肾增膜方颗粒对冻融胚胎解冻移植患者妊娠结局的影响

Effect of Bushen Zengmo granules on pregnancy outcome of freeze-thaw embryo transplantation

作者：蔡靓李丽宗道宽赵以琳刘希茹童国庆

英文作者：Cai Liang Li Li Zong Daokuan Zhao Yilin Liu Xiru Tong Guoqing

单位：上海中医药大学附属曙光医院生殖医学中心201203 

英文单位：Reproductive Medicine Centre Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

关键词：冻融胚胎解冻移植；补肾增膜方；黄体支持；子宫内膜容受性

英文关键词：Freeze-thawembryotransplantation；BushenZengmogranules；Corpuslutealsupport；Endometrialreceptivity

• 摘要：

• 【摘要】目的    探讨补肾增膜方颗粒对冻融胚胎解冻移植（FET）患者妊娠结局的影响。方法    选取2017年6月至2018年12月于上海中医药大学附属曙光医院生殖医学中心行FET的90例患者，完全随机分为对照组和观察组，各45例。对照组患者移植当日给予黄体支持至移植后14 d，对成功妊娠的患者黄体持续支持至孕6周；观察组患者于冻胚移植当月月经第2或3天开始服用补肾增膜方颗粒，在移植当日给予黄体支持至孕6周。行彩色多普勒超声于胚胎移植当日检测2组患者子宫内膜厚度、子宫动脉搏动指数及阻力指数。记录2组患者术后14 d的β-人绒毛膜促性腺激素(β-HCG)。记录2组患者移植后临床妊娠率、持续妊娠率。结果    观察组子宫内膜厚度与子宫动脉搏动指数明显大于对照组［（11.0±1.4）mm比（9.9±2.0）mm、（1.58±0.41）比（1.46±0.35）］，而子宫动脉阻力指数明显低于观察组［（0.47±0.17）比（0.59±0.13）］，差异均有统计学意义（均P＜0.05）。观察组患者胚胎移植后第14天血清β-HCG水平、临床妊娠率及持续妊娠率均明显高于对照组［（694±214）U/L比（580±346）U/L、60.0%（27/45）比40.0%（18/45）、92.6%（25/27）比77.8%（14/18）］，差异均有统计学意义（均P＜0.05）。结论    补肾增膜方颗粒能显著提高FET患者的妊娠成功率，其机制与改善子宫内膜容受性，调节β-HCG有一定的关系。

• 【Abstract】Objective    To investigate the effect of Bushen Zengmo granules on pregnancy outcome of freeze-thaw embryo transplantation(FET). Methods    Ninety patients undergoing FET at the Reproductive Medicine Center of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from June 2017 to December 2018 were randomly divided into control group and observation group, with 45 cases in each group. The control group received corpus luteum support since the day after transplantation for 14 days; patients with successful conception were treated with corpus luteum for 6 weeks. The observation group took Bushen Zengmo granules since the 2nd or 3rd day of menstruation in the month of transplantation and received corpus luteum support after transplantation for 6 weeks. Endometrial thickness, uterine artery pulse index(PI)and resistance index(RI) of endometrial blood flow were recorded by color Doppler ultrasound on the day of transplantation. Serum level of β-human chorionic gonadotropin（β-HCG） was detected 14 days after transplantation. Clinical pregnancy rate and sustained pregnancy rate were recorded. Results    Endometrial thickness and PI of uterine artery in observation group were significantly higher and RI of uterine artery was lower than those in control group［（11.0±1.4）mm vs （9.9±2.0）mm, （1.58±0.41） vs （1.46±0.35）, （0.47±0.17） vs （0.59±0.13）］(all P＜0.05). Level of serum β-HCG, clinical pregnancy rate and sustained pregnancy rate in observation group were significantly higher than those in control group［（694±214）U/L vs （580±346）U/L, 60.0%（27/45） vs 40.0%（18/45）, 92.6%（25/27） vs 77.8%（14/18］（all P＜0.05）. Conclusion    Bushen Zengmo granules can effectively improve the success rate of pregnancy in patients undergoing FET; the mechanisms are related with the improvement of endometrial receptivity and the regulation of β-HCG.