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单位:南京鼓楼医院南京大学医学院附属鼓楼医院泌尿外科210000
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关键词:前列腺癌根治术;膈下疼痛;二氧化碳;气腹压;机器人;腹腔镜
英文关键词:
【摘要】目的 探究不同二氧化碳气腹压对机器人辅助腹腔镜前列腺癌根治术后膈下疼痛的影响。方法 选取2018年2月至2019年2月在南京鼓楼医院泌尿外科行机器人辅助腹腔镜前列腺癌根治术患者180例,采用随机数字表法分为低、中、高气腹压组,每组60例。高气腹压组二氧化碳气腹压为14 mmHg(1 mmHg=0.133 kPa),中气腹压组为12 mmHg,低气腹压组为10 mmHg。对比3组术后膈下疼痛开始时间、膈下疼痛发生率、镇痛药使用率以及术后不同时点膈下疼痛程度评分。结果 低气腹压组术后膈下疼痛开始时间晚于中气腹压组和高气腹压组[(8.6±1.8)h比(7.7±1.5)、(7.0±1.0)h],术后48 h内膈下疼痛发生率及镇痛药使用率均低于中气腹压组和高气腹压组[10.0%(6/60)比23.3%(14/60)、33.3%(20/60),5.0%(3/60)比21.7%(13/60)、35.0%(21/60)],术后初次疼痛和术后12、24、48 h膈下疼痛程度评分均低于中气腹压组和高气腹压组[(6.59±1.52)分比(7.83±1.83)、(8.76±1.13)分,(4.33±0.85)分比(6.34±1.03)、(7.76±1.58)分,(2.63±0.23)分比(5.34±1.06)、(6.58±1.23)分,(0.38±0.03)分比(3.16±0.66)、(4.30±0.74)分],差异均有统计学意义(均P<0.05);中气腹压组和高气腹压组上述指标比较,差异均无统计学意义(均P>0.05)。结论 10 mmHg二氧化碳气腹压应用于机器人辅助腹腔镜前列腺癌根治术患者可显著减轻术后膈下疼痛程度,降低镇痛药使用率。
【Abstract】Objective To investigate the effect of different pressures of carbon dioxide pneumoperitoneum on subphrenic pain after robot-assisted laparoscopic radical prostatectomy. Methods A total of 180 patients undergoing robot-assisted laparoscopic radical prostatectomy in Nanjing Drum Tower Hospital from February 2018 to February 2019 were enrolled. The patients were randomly divided into 3 groups(n=60) treated with high, medium and low pressures(14, 12, 10 mmHg) of carbon dioxide pneumoperitoneum. Incidence and onset time of subphrenic pain, use of analgesics and the degree of pain at different time points after operation were analyzed. Results The onset of subphrenic pain in patients treated with high pressure of carbon dioxide pneumoperitoneum was later, incidence of postoperative 48 h subphrenic pain and use rate of analgesics were lower than with medium and low pressures[(8.6±1.8)h vs (7.7±1.5),(7.0±1.0)h; 10.0%(6/60) vs 23.3%(14/60), 33.3%(20/60); 5.0%(3/60) vs 21.7%(13/60), 35.0%(21/60)]. Scores of pain severity at onset and 12, 24, 48 h after operation with high pressure were lower than with medium and low pressures of carbon dioxide pneumoperitoneum[(6.59±1.52) vs (7.83±1.83),(8.76±1.13); (4.33±0.85) vs (6.34±1.03),(7.76±1.58); (2.63±0.23) vs (5.34±1.06),(6.58±1.23); (0.38±0.03) vs (3.16±0.66),(4.30±0.74)](all P<0.05). No statistical differences were noticed between medium and low pressures(all P>0.05). Conclusion Carbon dioxide pneumoperitoneum using 10 mmHg pressure can significantly relieve pain and reduce analgesic use in patients undergoing robot-assisted laparoscopic radical prostatectomy.
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