2020 年第 1 期 第 15 卷

年龄对无远处转移的胃癌患者预后的影响

Effect of age on the prognosis of gastric cancer without distant metastasis

作者：王宏强陆风雁竺枫

英文作者：

单位：浙江省舟山医院血液科肿瘤化疗中心316000

英文单位：

关键词：胃癌；无远处转移；年龄；预后

英文关键词：

• 摘要：

• 【摘要】目的    探讨年龄对无远处转移的胃癌患者预后的影响。方法    收集2004—2009年美国国家癌症研究所监测、流行病学和最终结果（SEER）数据库中经病理明确诊断的无远处转移的胃癌患者14 436例，采用Kaplan-Meier单因素分析和Cox多因素回归模型分析年龄、性别、种族、婚姻状况对患者5年生存率的影响。结果    单因素分析结果显示年龄、婚姻状况、种族对患者5年生存率有明显影响（均P＜0.05），性别对患者5年生存率无明显影响（P=0.513）。多因素分析结果显示，66～75岁患者与≤55岁患者相比，具有显著生存优势（风险比=0.850，95%置信区间：0.784～0.922，P＜0.001）。在男性（风险比=0.851，95%置信区间：0.770～0.940）、女性（风险比=0.861，95%置信区间：0.747～0.993）、非亚裔（风险比=0.820，95%置信区间：0.751～0.895）和区域晚期肿瘤患者（风险比=0.887，95%置信区间：0.809～0.972）中，66～75岁患者与≤55岁患者相比，均具有显著生存优势（均P＜0.05）。结论    年龄是无远处转移的胃癌患者预后的重要影响因素。年龄66～75岁是影响患者预后的保护因素。

• 【Abstract】Objective    To investigate the effect of age on the prognosis of gastric cancer without distant metastasis. Methods    From 2004 to 2009, 14 436 patients with gastric cancer without distant metastasis were identified in the Surveillance, Epidemiology and End Results database of United States National Cancer Institute. Kaplan-Meier univariate analysis and Cox multivariate regression model were used to analyze the effects of age, sex, race and marital status on the 5-year survival rate. Results    Univariate analysis showed that the 5-year survival rate was associated with age, marital status and race（all P＜0.05）; sex showed no effect on the 5-year survival rate(P=0.513). Multivariate analysis showed that 66-75 years old patients had higher survival rates compared with those under 55 years old in all subjects［risk ratio=0.850, 95% confidence interval(CI): 0.784-0.922, P＜0.001］, males(risk ratio=0.851, 95%CI: 0.770-0.940), females(risk ratio=0.861, 95%CI: 0.747-0.993), non-Asian(risk ratio=0.820, 95%CI: 0.751-0.895) and patients with local advanced tumor(risk ratio=0.887, 95%CI: 0.809-0.972)(all P＜0.05). Conclusion    Age is an important prognostic factor in patients with gastric cancer without distant metastasis; 66-75 years old is a protective factor of the prognosis.