2019 年第 8 期 第 14 卷

鼠神经生长因子联合碳光子治疗仪局部照射治疗老年带状疱疹的临床效果及安全性分析

Clinical efficacy and safety of mouse nerve growth factor combined with carbon photon local irradiation in treatment of senile herpes zoster

作者：李俊捧曹发龙

英文作者：

单位：810007西宁，青海省人民医院皮肤科

英文单位：

关键词：带状疱疹；鼠神经生长因子；碳光子治疗仪；注射用腺苷钴胺

英文关键词：

• 摘要：

• 【摘要】目的    探讨鼠神经生长因子联合碳光子治疗仪局部照射治疗老年带状疱疹的临床效果及安全性。方法    选取2017年5月至2018年6月青海省人民医院收治的老年带状疱疹患者91例，依据随机数字表法分为观察组（45例）和对照组（46例）。对照组给予常规治疗联合注射用腺苷钴胺治疗，观察组给予常规治疗联合注射用鼠神经生长因子和碳光子治疗仪局部照射治疗。比较2组患者治疗1周后生存质量改善率、治疗前后疼痛视觉模拟量表（VAS）评分、治疗过程中不良反应的发生情况和出院1个月后带状疱疹后遗神经痛发生率。结果    治疗1周后，观察组生活、睡眠、饮食、情绪、社交改善率均高于对照组［60.0%(27/45)比39.1%（18/46）、44.4%（20/45）比21.7%（10/46）、66.7%（30/45）比43.5%（20/46）、62.2%（28/45）比34.8%（16/46）、62.2%（28/45）比37.0%（17/46）］，差异均有统计学意义（均P<0.05）。治疗前，2组患者VAS评分比较差异无统计学意义（P＞0.05）。治疗1、2、3周后观察组VAS评分均低于对照组［（5.0±1.6）分比（5.7±1.2）分、（4.0±1.2）分比（5.3±1.7）分、（2.6±0.8）分比（3.8±1.1）分］，差异均有统计学意义（均P<0.05）。治疗期间，观察组发生注射性疼痛2例，注射结束后疼痛消失；2组患者治疗3周内均无其他不良反应发生。出院1个月后电话随访，观察组后遗神经痛发生率低于对照组［22.2%(10/45)比45.7%（21/46）］，差异有统计学意义（P=0.018）。结论    鼠神经生长因子联合碳光子治疗仪局部照射对促进老年带状疱疹患者病情恢复、改善生存质量、缓解疼痛及预防后遗神经痛方面具有明显疗效。

• 【Abstract】Objective    To explore the clinical effect and safety of mouse nerve growth factor combined with carbon photon local irradiation on senile patients with herpes zoster. Methods    A total of 91 senile patients with herpes zoster admitted to Qinghai Provincial People′s Hospital from May 2017 to June 2018 were randomly divided into observation group (45 cases) and control group (46 cases). The control group was treated with conventional therapy combined with cobamamide for injection. The observation group was treated with conventional therapy combined with mouse nerve growth factor for injection and carbon photon local irradiation. Quality of life was assessed 1 week after treatment. Score of Visual Analogue Scale（VAS） for pain was assessed before and after treatment. Adverse reactions during treatment and postherpetic neuralgia 1 month after treatment were observed. Results    One week after treatment, improvement rates of life, sleep, diet, mood and social intercourse in observation group were significantly higher than those in control group［60.0%(27/45) vs 39.1%（18/46）, 44.4%（20/45） vs 21.7%（10/46）, 66.7%（30/45） vs 43.5%（20/46）, 62.2%（28/45） vs 34.8%（16/46）, 62.2%（28/45） vs 37.0%（17/46）］（all P<0.05). There was no significant difference of VAS score between groups before treatment（P＞0.05）. At 1, 2, 3 weeks after treatment, VAS scores in observation group were significantly lower than those in control group［（5.0±1.6） vs （5.7±1.2）, （4.0±1.2） vs （5.3±1.7）, （2.6±0.8） vs （3.8±1.1）］（all P<0.05）. Two cases of injection-induced pain occurred in observation group; no other adverse reaction was observed during 3 weeks of treatment. One month after discharge, the incidence of postherpetic neuralgia in observation group was significantly lower than that in control group［22.2%(10/45) vs 45.7%（21/46）］（P=0.018）. Conclusion    Mouse nerve growth factor combined with carbon photon local irradiation treating senile herpes zoster can promote recovery, improve quality of life, relieve pain and prevent postherpetic neuralgia.