2019 年第 7 期 第 14 卷

育龄期多囊卵巢综合征患者血清25-羟维生素D3及抗苗勒管激素水平的变化

Changes of serum 25-hydroxyvitamin D3 and anti-müllerian hormone in fertile women with polycystic ovary syndrome

作者：李佳梁超王克芳

英文作者：

单位：100029首都医科大学附属北京安贞医院妇产科

英文单位：

关键词：多囊卵巢综合征；维生素D；抗苗勒管激素

英文关键词：

• 摘要：

• 【摘要】目的    探讨育龄期多囊卵巢综合征(PCOS)患者血清25-羟维生素D3［25-(OH)D3］和抗苗勒管激素(AMH)水平与健康育龄期女性的差异。方法    选择2016年7月至2018年6月首都医科大学附属北京安贞医院妇产科门诊就诊的初诊育龄期PCOS患者120例(观察组),另选择本院同期体检健康、月经周期规律的育龄期女性120名为对照组，比较2组维生素D缺乏率以及血清25-(OH)D3和AMH水平的差异。结果    观察组维生素D缺乏率高于对照组［84.2%(101/120)比17.5%（21/120）］，差异有统计学意义（P<0.001）。观察组血清25-(OH)D3水平低于对照组［(14±6)μg/L比（24±6）μg/L］，血清AMH水平高于对照组［(7.5±3.8)μg/L比（4.1±2.1）μg/L］，差异均有统计学意义(均P＜0.001)。结论    与健康育龄期女性比较，PCOS患者血清25-(OH)D3水平明显降低，血清AMH水平显著升高。

• 【Abstract】Objective    To observe the levels of serum 25-hydroxyvitamin D3［25-(OH)D3］ and anti-müllerian hormone(AMH) in patients with polycystic ovary syndrome(PCOS) and healthy women of child-bearing age. Methods    From July 2016 to June 2018, 120 PCOS patients(observation group) and 120 healthy women of child-bearing age with regular menstrual cycle(control group) were enrolled in Beijing Anzhen Hospital, Capital Medical University. Vitamin D deficiency, serum levels of 25-(OH)D3 and AMH were analyzed. Results    Vitamin D deficiency rate in observation group was significantly higher than that in control group［84.2%(101/120) vs 17.5%(21/120)］(P<0.05). Serum 25-(OH)D3 level in observation group was significantly lower than that in control group［(14±6)μg/L vs (24±6)μg/L］(P<0.05). Serum AMH level in observation group was significantly higher than that in control group ［(7.5±3.8)μg/L vs (4.1±2.1)μg/L］(P<0.05). Conclusion    PCOS patients of child-bearing age show low serum 25-(OH)D3 level and elevated serum AMH level compared with healthy women.