2019 年第 7 期 第 14 卷

慢性阻塞性肺疾病急性加重期患者血浆纤维蛋白原和血清总胆红素水平的变化

Changes of plasma fibrinogen and serum total bilirubin in patients with acute exacerbation of chronic obstructive pulmonary disease

作者：庄琼馨钱粉红邓霞柳星星

英文作者：

单位：212001江苏省镇江市，江苏大学附属医院呼吸内科

英文单位：

关键词：慢性阻塞性肺疾病急性加重期；纤维蛋白原；总胆红素

英文关键词：

• 摘要：

• 【摘要】目的    探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者血浆纤维蛋白原（Fib）和血清总胆红素水平的变化及二者对AECOPD的诊断价值。方法    连续纳入2016年1月至2018年7月在江苏大学附属医院进行治疗的慢性阻塞性肺疾病患者107例，其中AECOPD 75例（观察组），慢性阻塞性肺疾病稳定期32例（对照组）。比较2组血浆Fib和血清总胆红素水平，分析二者单独及联合检测对AECOPD的诊断价值。结果    观察组入院24 h血浆Fib水平高于对照组［(4.6±1.3)g/L比（3.0±0.5）g/L］，而血清总胆红素水平低于对照组［(7.3±2.8)μmol/L比（11.5±3.9）μmol/L］，差异均有统计学意义（均P<0.001）。血浆Fib与血清总胆红素联合检测诊断AECOPD的曲线下面积大于二者单独检测（0.951比0.890、0.821）。结论    检测血浆Fib和血清总胆红素水平对AECOPD的诊断具有重要提示意义，二者联合检测对AECOPD的诊断价值更高。

• 【Abstract】Objective    To investigate the changes and diagnostic value of plasma fibrinogen and serum total bilirubin in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods    A total of 107 patients with chronic obstructive pulmonary disease admitted to the Affiliated Hospital of Jiangsu University from January 2016 to July 2018 were enrolled, including 75 patients with AECOPD(observation group) and 32 patients at stable stage(control group). Levels of plasma fibrinogen and serum total bilirubin were detected and their separate and joint diagnostic values for AECOPD were analyzed. Results    Plasma fibrinogen level in 24 h after admission in the observation group was significantly higher and serum total bilirubin level was lower than those in the control group［(4.6±1.3)g/L vs (3.0±0.5)g/L, (7.3±2.8)μmol/L vs (11.5 ± 3.9)μmol/L］(both P<0.001). Area under curve of combined detection with fibrinogen and total bilirubin in diagnosing AECOPD was greater than that of individual detection(0.951 vs 0.890, 0.821). Conclusions    Plasma fibrinogen and serum total bilirubin are of great significance in the diagnosis of AECOPD. Combined detection indicates higher diagnostic value.