2019 年第 5 期 第 14 卷

丁苯酞注射液联合依达拉奉治疗急性脑梗死的临床效果

Clinical effect of butylphthalide injection combined with edaravone on acute cerebral infarction

作者：藏君

英文作者：

单位：100144首都医科大学附属北京康复医院神经内科

英文单位：

关键词：急性脑梗死；依达拉奉；丁苯酞注射液；神经元特异性烯醇化酶；S-100β

英文关键词：

• 摘要：

• 【摘要】目的    观察丁苯酞注射液联合依达拉奉治疗急性脑梗死的临床效果。方法    回顾性分析2014年1月至2017年1月首都医科大学附属北京康复医院诊治的120例急性脑梗死患者的临床资料。所有患者按照治疗方法的不同分为对照组和观察组，各60例。对照组在常规治疗基础上给予丁苯酞注射液治疗，观察组患者在对照组基础上给予依达拉奉治疗。分析2组患者的临床治疗效果［美国国立卫生研究院卒中量表（NIHSS）评分及Barthel指数］及治疗前后S-100β和神经元特异性烯醇化酶(NSE)及白细胞介素(IL)水平变化。结果    治疗后，2组NIHSS评分较治疗前降低，Barthel指数评分较治疗前升高，且观察组NIHSS评分低于对照组，Barthel指数评分高于对照组［（7.5±0.9）分比（10.3±1.9）分、（52±8）分比（47±7）分］，差异均有统计学意义（均P<0.05）。治疗后，2组S-100β、NSE、IL-1、IL-2及IL-6水平均较治疗前下降，且观察组低于对照组，差异均有统计学意义（均P<0.05）。结论    依达拉奉能有效增强丁苯酞注射液对急性脑梗死的临床效果，且此过程可能与调控患者血清中S-100β、NSE及IL水平有关。

• 【Abstract】Objective    To observe the clinical efficacy of butylphthalide injection combined with edaravone in the treatment of acute cerebral infarction. Methods    Clinical data of 120 patients with acute cerebral infarction admitted to Beijing Rehabilitation Hospital of Capital Medical University from January 2014 to January 2017 were retrospectively analyzed. The patients were divided into control group treated by butylphthalide injection and observation group treated by butylphthalide injection plus edaravone. Clinical therapeutic effect was evaluated by National Institutes of Health Stroke Scale(NIHSS) score and Barthel index score. Blood levels of S-100β, neuron-specific enolase(NSE) and interleukin(IL) were analyzed before and after treatment. Results    After treatment, NIHSS score significantly decreased and Barthel index significantly increased in both groups; NIHSS score in observation group was significantly lower and Barthel index score was higher than those in control group［（7.5±0.9）scores vs （10.3±1.9）scores, （52±8）scores vs （47±7）scores］（all P<0.05）. After treatment, levels of S-100β, NSE, IL-1, IL-2 and IL-6 significantly decreased in both groups and the levels in observation group were significantly lower than those in control group(all P<0.05). Conclusion    Edaravone can effectively enhance the clinical effect of butylphthalide injection on acute cerebral infarction, which may be related to its regulation on serum S-100β, NSE and interleukin.