2019 年第 3 期 第 14 卷

右美托咪定对磷脂酰肌醇-3-激酶/蛋白激酶_B信号通路的影响研究进展

Research progress of dexmedetomidine on phosphatidylmyosidyl 3-kinase/protein kinase B signaling pathway

作者：刘烨解雅英

英文作者：

单位：010050呼和浩特，内蒙古医科大学附属医院麻醉科

英文单位：

关键词：右美托咪定；细胞凋亡；磷脂酰肌醇-3-激酶/蛋白激酶B；缺血再灌注损伤

英文关键词：

• 摘要：

• 【摘要】磷脂酰肌醇-3-激酶/蛋白激酶 B （PI3K/Akt）信号通路是典型的抗凋亡通路。右美托咪定是新型的高选择性α2-肾上腺素受体激动剂，因其副作用少，具有多器官保护作用而被广泛应用于临床。右美托咪定通过激活PI3K/Akt信号通路，可以抑制或增强下游相关靶蛋白的表达进而发挥其特定的保护作用。本文对右美托咪定对PI3K/Akt信号通路的影响研究进展进行了综述。

• 【Abstract】Phosphatidylmyosidyl 3-kinase/protein kinase B(PI3K/Akt) is a typical anti-apoptosis signaling pathway. Dexmedetomidine is a novel high selectivity α2-adrenergic receptor agonist which is widely used in clinical practice because of its multi-organ protective effect and low side effects. Dexmedetomidine can up or down regulate downstream target proteins and then plays specific protective roles through activating PI3K/Akt signaling pathway. This paper reviewed advanced researches on the effect of dexmedetomidine on PI3K/Akt signaling pathway.