2019 年第 1 期 第 14 卷

卡贝缩宫素联合Bakri子宫球囊控制产后出血的效果

Effect of carbetocin combined with Bakri balloon tamponade on postpartum hemorrhage

作者：周莉娜洪莉

英文作者：

单位：430060武汉大学人民医院妇产科

英文单位：

关键词：产后出血；卡贝缩宫素；Bakri子宫球囊；凝血功能

英文关键词：

• 摘要：

• 【摘要】目的    探究卡贝缩宫素联合Bakri子宫球囊控制足月分娩产妇产后出血的效果。方法    选取2016年8月至2017年8月武汉大学人民医院足月分娩产妇196例，采用随机数字表法分为对照组和观察组，每组98例。对照组分娩结束后接受静脉注射卡贝缩宫素注射液治疗（100 μg），观察组在对照组的基础上接受Braki子宫球囊导管填塞治疗。记录2组产妇分娩时及分娩后2、24 h的出血量，计算产后出血的治疗有效率，检测分娩前和分娩后24 h的凝血功能指标，观察分娩后生命体征及血常规相关指标。结果    观察组分娩后2、24 h出血量均明显少于对照组［（48±17）ml比（88±21）ml、（209±41）ml比（380±65）ml］(均P＜0.01)。观察组治疗有效率明显高于对照组［94.9%（93/98）比84.7%（83/98）］（P＝0.02）。2组分娩前及分娩后24 h凝血酶原时间、纤维蛋白原、活化部分凝血活酶时间比较差异均无统计学意义(均 P＞0.05)。2组分娩后生命体征及血常规相关指标差异均无统计学意义(均P＞0.05)。结论    卡贝缩宫素联合Braki子宫球囊控制患者产后出血效果好。

• 【Abstract】Objective    To analyze the effect of carbetocin combined with Barki blloon tamponade on postpartum hemorrhage in full-term puerperants. Methods    From August 2016 to August 2017, a total of 196 full-term puerperants in Renmin Hospital of Wuhan University were randomly divided into observation group and control group, with 98 cases in each group. The control group was treated with intravenous injection of carbetocin（100 μg） after delivery. The observation group was treated with carbetocin combined with Barki balloon tamponade after delivery. Blood loss during delivery and blood loss in 2, 24 h after delivery were recorded. Therapeutic effect on postpartum bleeding was analyzed. Coagulation function indexes were tested before and 24 h after delivery. Vital signs and blood routine indicators were observed after delivery. Results    Amounts of bleeding in 2, 24 h after delivery in the observation group were significantly less than those in the control group［（48±17）ml vs （88±21）ml, （209±41）ml vs （380±65）ml］(P＜0.01). The therapeutic effective rate in the observation group was significantly higher than that in the control group［94.9%（93/98） vs 84.7%（83/98）］（P＝0.02）. There were no statistical differences of prothrombin time, fibrinogen and partial thromboplastin time between groups before and 24 h after delivery(P＞0.05). There were no statistical differences of vital signs and blood routine indicators between groups after delivery(P＞0.05). Conclusion    Intravenous injection of carbetocin combined with Bakri balloon tamponade can effectively reduce postpartum hemorrhage.