2019 年第 1 期 第 14 卷

缺氧诱导因子1α在非小细胞肺癌组织中的表达及其与患者临床预后的关系

Relation between expression of hypoxia inducible factor-1α and clinical prognosis in patients with non-small cell lung cancer

作者：蒋友国邓三明罗剑刘军涛潘亮亮王韬渊

英文作者：

单位：300162天津，武装警察部队后勤学院附属医院胸心血管外科

英文单位：

关键词：非小细胞肺癌；缺氧诱导因子1α；血管内皮生长因子

英文关键词：

• 摘要：

• 【摘要】目的    观察缺氧诱导因子1α（HIF-1α）在非小细胞肺癌组织中的表达及其与患者临床预后的关系。方法    选取2015年1月至2017年1月于武装警察部队后勤学院附属医院首诊新发非小细胞肺癌患者120例。使用免疫组织化学法测定患者初诊肺活检组织中HIF-1α蛋白表达水平，并收集患者1年随访的短期预后情况，分析HIF-1α表达对转移/复发以及死亡的影响。结果    HIF-1α阳性患者中血管内皮生长因子(VEGF)和VEGF受体2（VEGFR2）阳性者比例均高于HIF-1α阴性患者［77.3%（68/88）比65.6%（21/32）、75.0%（66/88）比62.5%（20/32）］，差异均有统计学意义（均P<0.05）。随访1年间共有17例患者转移/复发，HIF-1α阳性患者的转移/复发率高于HIF-1α阴性患者［17.0%（15/88）比6.2%（2/32）］，差异有统计学意义（P<0.05）；有6例患者死亡，其中4例HIF-1α阳性，2例HIF-1α阴性。Logistic回归分析结果显示，HIF-1α阳性以及VEGF和VEGFR2阳性均为首诊新发非小细胞肺癌患者转移/复发、死亡以及合计不良预后的危险因素，比值比均大于1，均P<0.05。结论    HIF-1α阳性以及VEGF和VEGFR2阳性均为非小细胞癌转移/复发、死亡以及合计不良预后的危险因素。

• 【Abstract】Objective    To investigate the expression of hypoxia inducible factor-1α(HIF-1α) in non-small cell lung cancer and the impact on prognosis. Methods    From January 2015 to January 2017, 120 patients with newly diagnosed non-small cell lung cancer in the Affiliated Hospital of Logistics College of Chinese People′s Armed Police Forces were enrolled. Expression of HIF-1α in lung biopsy tissue was tested by immunohistochemistry. Prognosis of patients was observed in 1 year after discharge. The relation between HIF-1α expression and metastasis/recurrence or death was analyzed. Results    Positive rates of vascular endothelial growth factor(VEGF) and VEGF receptor 2(VEGFR2) in HIF-1α positive patients were significantly higher than those in HIF-1α negative patients［77.3%（68/88） vs 65.6%（21/32）, 75.0%（66/88） vs 62.5%（20/32）］（P<0.05）. During 1-year follow-up, 17 patients had metastasis or recurrence; the rate of metastasis/recurrence in HIF-1α positive patients was significantly higher than that in HIF-1α negative patients［17.0%（15/88） vs 6.2%（2/32）］(P<0.05). There were 6 deaths, including 4 cases of HIF-1α positive and 2 cases of HIF-1α negative. Logistic regression analysis suggested that HIF-1α, VEGF and VEGFR2 positive expression were risk factors of metastasis/recurrence and death in non-small cell lung cancer patients(odds ratio＞1, P<0.05). Conclusion    HIF-1α, VEGF and VEGFR2 positive expression are risk factors of metastasis, recurrence and death in non-small cell lung cancer atients.