2018 年第 12 期 第 13 卷

同型半胱氨酸水平与肺血栓栓塞症的相关性研究进展

Research progress of correlation between homocysteine and pulmonary thromboembolism

作者：蒋容邢柏

英文作者：

单位：570311海口，海南医学院第二附属医院急诊科

英文单位：

关键词：肺血栓栓塞症；同型半胱氨酸；高同型半胱氨酸血症

英文关键词：

• 摘要：

• 【摘要】同型半胱氨酸是一种反应性血管受损的氨基酸，其代谢过程中无论哪一种酶或辅助因子异常，均可形成代谢紊乱，导致高同型半胱氨酸血症。肺血栓栓塞症具有临床症状不典型、预后差、病死率高等特点，临床上诊断困难，漏诊率、误诊率高，因此掌握肺血栓栓塞症高危因素对提高其正确诊断率及合理治疗具有重要意义。目前已有研究证实，高同型半胱氨酸血症是肺栓塞的独立危险因素,高同型半胱氨酸血症可通过内皮损伤、血管平滑肌增殖、凝血和纤溶系统失衡引起血栓形成。

• 【Abstract】Homocysteine(Hcy) is a reactive vascular-damaged amino acid. During the metabolic process, abnormalities of enzymes or cofactors may lead to Hcy metabolic disturbance even hyperhomocysteinemia(HHcy). Pulmonary thromboembolism has untypical clinical symptoms, poor prognosis and high mortality. It is difficult to make early diagnosis and the rates of missed diagnosis and misdiagnosis are high. HHcy has been confirmed as an independent risk factor of pulmonary embolism. HHcy can cause thrombosis through endothelial damage, vascular smooth muscle proliferation, coagulation and fibrinolysis imbalance.