2018 年第 12 期 第 13 卷

“互联网+”背景下心脏机械瓣膜置换术后患者华法林抗凝治疗的研究进展

Research progress of anticoagulant therapy in patients with mechanical aortic valve replacement under the context of "Internet+"

作者：朱治辉张海波焦玉清孟旭

英文作者：

单位：100029首都医科大学附属北京安贞医院心外科

英文单位：

关键词：机械瓣置换术；“互联网+”；华法林；抗凝

英文关键词：

• 摘要：

• 【摘要】心脏瓣膜置换术是治疗严重心脏瓣膜病的有效手段，在我国，机械瓣的使用率接近70%。机械瓣置换术后需要终身抗凝，而华法林是一种有效抗凝血剂，具有广泛的使用率，但具有治疗窗窄，个体、民族间差异大的特点，易发生出血或血栓等并发症。因此华法林的合理用药已经成为心脏瓣膜置换术后的重要问题。本文综述了“互联网+”背景下心脏瓣膜置换术后患者华法林抗凝治疗的最新研究进展，期待为心脏外科医生更好地开展术后随诊、减少患者术后并发症提供新思路。

• 【Abstract】Heart valve replacement is an effective method for the treatment of severe valvular heart disease. Among them, the use rate of mechanical valves is close to 70% in China. Patients with mechanical valve replacement need lifelong anticoagulation therapy. Warfarin is an effective and widely used anticoagulant. However, it has a narrow therapeutic window and great differences among individuals and nationalities. Complications such as bleeding and thrombosis are prone to occur. Therefore, rational use of warfarin has become an important issue for patients after valve replacement. Under the context of "Internet +", many new progresses of warfarin anticoagulant therapy in patients with mechanical heart valve replacement have been developed, providing new ideas for cardiac surgeons to follow up patients and reduce complications after operation.