2018 年第 12 期 第 13 卷

老年冠状动脉粥样硬化性心脏病患者B型脑钠肽与冠状动脉病变程度的关系

Relation between brain natriuretic peptide and severity of coronary artery lesion in elderly patients with coronary atherosclerotic heart disease

作者：贾淑杰周芸王阳冯婷婷赵欣张涛

英文作者：

单位：100029首都医科大学附属北京安贞医院特需医疗科

英文单位：

关键词：冠状动脉粥样硬化性心脏病；B型脑钠肽；冠状动脉病变

英文关键词：

• 摘要：

• 【摘要】目的    探讨老年冠状动脉粥样硬化性心脏病（冠心病）患者B型脑钠肽（BNP）与冠状动脉病变程度的关系。方法    选取2014年1月至2016年6月于首都医科大学附属北京安贞医院因胸痛症状就诊的年龄≥60岁的老年心内科住院患者200例为研究对象。根据本院冠状动脉CT或冠状动脉造影检查结果分为冠心病组和对照组，各100例。冠心病组分为单支病变组（41例）、双支病变组（37例）、多支病变组（22例）和复杂病变组（35例，包括多支血管病变）。比较各组的基线临床特征和同型半胱氨酸（Hcy）、高敏C反应蛋白（hs-CRP）、BNP水平。结果    各组年龄、体重指数、吸烟史、高血压史、收缩压、舒张压、空腹血糖、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、血尿酸及超声心动图指标差异均无统计学意义（均P>0.05）。单支病变组、双支病变组、多支病变组、复杂病变组Hcy、hs-CRP、BNP水平［（150±9）、（155±10）、（166±13）、（176±9）ng/L比（71±4）ng/L］高于对照组，差异均有统计学意义（均P<0.05）。结论    BNP水平是冠心病患者冠状动脉病变严重程度的预测指标。

• 【Abstract】Objective    To explore the relation between brain natriuretic peptide(BNP) and severity of coronary artery lesion in elderly patients with coronary atherosclerotic heart disease（CHD）. Methods    From January 2014 to June 2016, 200 hospitalized elderly patients(≥60 years old) with chest pain were enrolled in Beijing Anzhen Hospital, Capital Medical University. According to the Results of coronary CT or angiography, the patients were divided into CHD group and control group, with 100 cases in each group. The CHD group was divided into single vessel disease group(n＝41), double vessel disease group(n＝37), multi-vessel disease group(n＝22) and complex disease group(n＝35, including multi-vessel disease). Baseline clinical characteristics, homocysteine（Hcy）, high sensitive C-reactive protein（hs-CRP） and BNP levels were analyzed. Results    There were no significant differences of age, body mass index, smoking history, hypertension history, systolic blood pressure, diastolic blood pressure, fasting blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, serum uric acid and echocardiographic indexes among groups(P>0.05). Levels of Hcy, hs-CRP and BNP ［（150±9）,（155±10）,（166±13）,（176±9）ng/L vs （71±4）ng/L］ in the single vessel disease group, double vessel disease group, multi-vessel disease group and complex disease group were higher than those in the control group(P<0.05). Conclusion    BNP is a predictor of the severity of coronary artery disease in CHD patients.