2018 年第 10 期 第 13 卷

养心汤加减治疗睡眠呼吸暂停综合征患者的临床效果

Clinical effect of Yangxin decoction on patients with sleep apnea syndrome

作者：刘新桥王玲

英文作者：

单位：100029首都医科大学附属北京安贞医院中医理疗科

英文单位：

关键词：睡眠呼吸暂停综合征；养心汤；加减治疗

英文关键词：

• 摘要：

• 【摘要】目的    探讨养心汤加减治疗睡眠呼吸暂停综合征患者的临床效果。方法    纳入2017年1月至2018年2月于首都医科大学附属北京安贞医院中医理疗科门诊就诊的睡眠呼吸暂停综合征患者100例，按照随机数字表法分为对照组和观察组，各50例。对照组患者仅进行西医治疗；观察组在对照组西医治疗基础上给予中医养心汤治疗。比较2组患者治疗效果、治疗后多导睡眠图监测指标、Ep-worth嗜睡量表（ESS）和蒙特利尔认知评估量表（MoCA）评分、患者及家属对治疗的满意情况。结果    观察组患者治疗总有效率明显高于对照组［98.0%（49/50）比84.0%（42/50）］，差异有统计学意义（P＜0.05）。观察组患者治疗后最长呼吸暂停时间、呼吸暂停低通气指数、脉压水平均明显低于对照组，夜间最低血氧饱和度水平明显高于对照组，差异均有统计学意义（均P＜0.05）。治疗后，观察组患者ESS评分明显低于对照组［（2.9±1.4）分比（4.0±1.6）分］，MoCA评分明显高于对照组［（27±4）分比（24±4）分］，差异均有统计学意义（均P＜0.05）。观察组患者及家属对治疗的总满意度明显高于对照组［96.0%（48/50）比76.0%（38/50）］，差异有统计学意义（P＜0.05）。结论    养心汤加减治疗睡眠呼吸暂停综合征患者的临床效果明显，可有效改善患者呼吸循环和睡眠结构，提高认知功能，降低嗜睡程度，患者满意度较高。

• 【Abstract】Objective    To explore the clinical effect of Yangxin decoction on patients with sleep apnea syndrome. Methods    From January 2017 to February 2018, 100 patients with sleep apnea syndrome admitted to Department of Traditional Chinese Medicine Physiotherapy, Beijing Anzhen Hospital, Capital Medical University were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with western medicine. The observation group was treated with Yangxin decoction on the basis of western medicine. Clinical therapeutic effect, polysomnogram parameters, Ep-worth Sleepiness Scale（ESS）, Montreal Cognitive Assessment(MoCA) and patient satisfaction were analyzed. Results    The total effective rate in the observation group was significantly higher than that in the control group［98.0%（49/50） vs 84.0%（42/50）］（P＜0.05）. After treatment, the longest apnea time, apnea hypopnea index, pulse pressure level in the observation group were significantly lower and the lowest blood oxygen saturation during night was significantly higher than those in the control group（P＜0.05）. After treatment, ESS score in the observation group was significantly lower than that in the control group［（2.9±1.4） vs （4.0±1.6）］; MoCA score in the observation group was significantly higher than that in the control group［（27±4） vs （24±4）］(P＜0.05). The total patient satisfaction in the observation group was significantly higher than that in the control group［96.0%（48/50） vs 76.0%（38/50）］（P＜0.05）. Conclusions    Yangxin decoction has a good therapeutic effect on sleep apnea syndrome. It can effectively improve respiratory circulation and sleep architecture, reduce somnolence and improve cognitive function.