2018 年第 7 期 第 13 卷

颈动脉狭窄稳定斑块与易损斑块患者的临床特征分析

Clinical features of stable plaques and unstable plaques of carotid artery stenosis

作者：杨耀国陈忠唐小斌寇镭吴章敏刘晖王盛

英文作者：

单位：100029首都医科大学附属北京安贞医院血管外科

英文单位：

关键词：颈动脉斑块；动脉粥样硬化；稳定性；磁共振成像

英文关键词：

• 摘要：

• 【摘要】目的    比较磁共振成像提示颈动脉粥样硬化斑块稳定与易损患者临床特征的差异。方法    选择2013年5月至2017年10月于首都医科大学附属北京安贞医院血管外科住院治疗的颈动脉狭窄患者211例。依据磁共振检查结果分为稳定斑块组（69例）与易损斑块组（142例），通过收集患者临床资料，包括基线资料、临床症状以及相关实验室指标，分析不同稳定性的颈动脉斑块所表现的临床特征是否有差异。结果    稳定斑块组患者平均动脉压低于易损斑块组［(90±8)mmHg（1 mmHg=0.133 kPa）比（95±10）mmHg］，缺血性脑卒中率低于易损斑块组［10.1%(7/69)比25.4%（36/142）］，差异均有统计学意义（均P<0.05），2组患者其他基线资料、既往史和临床症状、各实验室指标检测结果比较差异均无统计学意义（均P＞0.05）。结论    平均动脉压较高及已出现缺血性脑卒中的颈动脉斑块更倾向于不稳定，而其他临床特征的差异性尚待进一步分析。

• 【Abstract】Objective    To compare the clinical features of carotid artery stenosis patients with stable plaques and unstable plaques indicated by magnetic resonance imaging. MethodTotally 211 patients with carotid artery stenosis in Beijing Anzhen Hospital, Capital Medical University from May 2013 to October 2017 were analyzed. According to Results     of magnetic resonance imaging, the patients were divided into stable plaque group（n＝69） and unstable plaque group（n＝142）. Clinical baseline data, symptoms and laboratory indicators were analyzed. Results     Mean arterial pressure in stable plaque group was significantly lower than that in unstable plaque group［(90±8)mmHg vs（95±10）mmHg］（P<0.05）. Ischemic stroke rate in stable plaque group was significantly lower than that in unstable plaque group［10.1%(7/69)vs 25.4%（36/142）］（P<0.05）. Medical histories, clinical symptoms and laboratory indicators showed no significant differences between groups（P＞0.05）. Conclusion    Carotid plaques in patients with high mean arterial pressure and ischemic stroke are unstable.

  【Key words】Carotid plaque;Arteriosclerosis;Stability;Magnetic resonance imaging

  【Fund program】National Natural Science Foundation of China(81070256, 81570435）