设为首页 电子邮箱 联系我们

本刊最新招聘信息请见“通知公告”!  本刊投稿系统试运行中,欢迎投稿!如投稿有问题,可直接将稿件发送至zgyy8888@163.com

 

主管单位:中华人民共和国   

国家卫生健康委员会

主办单位:
总编辑:
杨秋

编辑部主任:吴翔宇

邮发代号:80-528
定价:28.00元
全年:336.00元
Email:zgyy8888@163.com
电话(传真):010-64428528;
010-64456116(总编室)

                  

2018 年第 5 期 第 13 卷

雌激素受体和组织蛋白酶B及盆底功能障碍性疾病的相关性研究

Relation among estrogen receptor, cathepsin B and pelvic floor dysfunction

作者:陈红香虞海荣古丽加娜提王琳王芬韩涛昆多孜·乌赛那洪

英文作者:

单位:830001乌鲁木齐,新疆维吾尔自治区人民医院妇科

英文单位:

关键词:盆底功能障碍性疾病;组织蛋白酶B;雌激素受体

英文关键词:

  • 摘要:
  • 目的    分析雌激素受体(ER)和组织蛋白酶B(CB)及盆底功能障碍性疾病(PFD)的相关性。方法    选取2015年1月至2016年10月新疆维吾尔自治区人民医院收治的因PFD行子宫全切术的绝经后女性患者32例作为观察组,以同期无PFD、因妇科良性疾病做子宫全切术的绝经后女性患者32例作为对照组。通过免疫组织化学方法检测阴道壁中ER、CB表达水平及阳性率。CB与ER的相关性分析采用Spearman秩和检验。结果    观察组ER-α的测定值及ER-α、ER-β的阳性率高于对照组[(30±6)%比(20±10)%、66.15%比25.96%、57.33%比16.53%],差异均有统计学意义(均P<0.05);观察组ER-β的测定值略高于对照组[(14±5)%比(10±5)%],差异无统计学意义(P>0.05)。观察组CB的测定值及阳性率均低于对照组[(3.8±0.3)%比(5.0±0.4)%、23.43%比82.01%],差异均有统计学意义(均P<0.05)。CB水平与ER-α及ER-β表达水平均呈负相关关系(r=-0.646、-0.602,均P<0.05)。结论    PFD患者ER水平升高,CB下降,CB和ER水平呈负相关关系。

  • 【Abstract】Objective    To analyze the relation among estrogen receptor(ER), cathepsin B(CB) and pelvic floor dysfunction(PFD). Methods    Thirty-two postmenopausal women with PFD undergoing total hysterectomy from January 2015 to October 2016 in People′s Hospital of Xinjiang Uygur Antonomous Region were enrolled as observation group; 32 postmenopausal women undergoing total hysterectomy for benign gynecologic disease were enrolled as control group. Expressions of ER and CB in vaginal wall were tested by immunohistochemical method and the correlation between them was analyzed by Spearman test. Results    Value of ER-α and positive rates of ER-α and ER-β in observation group were significantly higher than those in control group[(30±6)% vs (20±10)%, 66.15% vs 25.96%, 57.33% vs 16.53%](P<0.05). Value of ER-β in observation group was higher than that in control group[(14±5)% vs (10±5)%](P>0.05). Value and positive rate of CB in observation group were significantly lower than those in control group[(3.8±0.3)% vs (5.0±0.4)%, 23.43% vs 82.01%](P<0.05). Spearman test showed that CB expression was negatively correlated with ER-α and ER-β(r=-0.646, -0.602; P<0.05). Conclusion    Expression of ER increases and CB decreases in patients with PFD; there is a negative correlation between expressions of CB and ER.

    【Key words】Pelvic floor dysfunction;Cathepsin B;Estrogen receptor

    【Fund program】Research Project of People′s Hospital of Xinjiang Uygur Autonomous Region(20150119)


copyright
地址:北京市朝阳区安贞路2号首都医科大学附属北京安贞医院北楼二层
电话:010-64456116 传真:010-64428528 邮编:100029 Email: zgyy8888@163.com
网址: 京ICP备2020043099号-3

当您在使用本网站投稿遇到困难时,请直接将稿件投送到编辑部邮箱zgyy8888@163.com。







安卓


苹果

关闭
Baidu
map