2018 年第 5 期 第 13 卷

强化剂量阿托伐他汀对冠状动脉介入术后老年患者血脂及血清高敏C反应蛋白水平的影响

Effect of enhanced dose atorvastatin on serum lipid and high-sensitivity C-reactive protein in elderly patients after coronary intervention

作者：刘嫦玉苏屿吴丽婷

英文作者：

单位：570311海口，海南省人民医院检验科

英文单位：

关键词：经皮冠状动脉介入；阿托伐他汀；高敏C反应蛋白

英文关键词：

• 摘要：

• 目的    探讨强化剂量阿托伐他汀对经皮冠状动脉介入（PCI）术后老年患者血脂及血清高敏C反应蛋白（hs-CRP）水平的影响。方法    选取2016年7月至2017年7月于海南省人民医院行PCI术的68例冠状动脉粥样硬化性心脏病患者作为研究对象，采用抛硬币法随机分为观察组和对照组，每组34例。对照组患者在常规治疗基础上给予阿托伐他汀10 mg口服治疗，每晚1次；观察组患者在常规治疗基础上给予阿托伐他汀80 mg口服治疗，每晚1次。比较2组患者治疗前后总胆固醇、三酰甘油、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及hs-CRP水平。结果    治疗前，2组患者总胆固醇、三酰甘油、LDL-C及HDL-C水平比较，差异均无统计学意义（均P＞0.05）。2组患者治疗后总胆固醇、三酰甘油、LDL-C水平均明显低于治疗前，HDL-C水平均明显高于治疗前，且观察组患者治疗后总胆固醇、LDL-C水平明显低于对照组，HDL-C水平明显高于对照组，差异均有统计学意义（均P＜0.05）。治疗前，观察组与对照组hs-CRP水平比较［（11.2±5.2）mg/L比（10.8±5.1）mg/L］，差异无统计学意义（P＞0.05），治疗后，观察组与对照组患者的hs-CRP水平［（4.2±1.8）、（7.0±2.9）mg/L］均明显低于本组治疗前，且观察组患者hs-CRP水平明显低于对照组，差异均有统计学意义（均P＜0.05）。结论    强化剂量阿托伐他汀应用于PCI术后老年患者能有效降低血脂及hs-CRP水平，增强抗炎作用。

• 【Abstract】Objective    To analyze the effect of enhanced dose atorvastatin on serum lipid and high-sensitivity C-reactive protein(hs-CRP) in elderly patients after percutaneous coronary intervention（PCI）. Methods    A total of 68 cornary heart disease patients undergoing PCI from July 2016 to July 2017 in Hainan General Hospital were randomly divided into observation group(n=34) and control group(n=34). The control group took atorvastatin 10 mg every evening; the observation group took atorvastatin 80 mg every evening. Levels of total cholesterol, triacylglycerol, low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C) and hs-CRP were analyzed before and after treatment. Results    There were no significant differences of total cholesterol, triacylglycerol, LDL-C and HDL-C levels between groups before treatment(P＞0.05). After treatment, levels of total cholesterol, triacylglycerol and LDL-C were significantly lower and HDL-C was significantly higher than those before treatment in both groups; levels of total cholesterol and LDL-C in observation group were significantly lower and HDL-C was significantly higher than those in control group(P＜0.05). Level of hs-CRP before treatment had no significant difference between observation group and control group［（11.2±5.2）mg/L vs （10.8±5.1）mg/L］(P＞0.05). After treatment, level of hs-CRP was significantly lower than that before treatment in both groups; level of hs-CRP in observation group［（4.2±1.8）mg/L］ was significantly lower than that in control group［（7.0±2.9）mg/L］(P＜0.05). Conclusion    Enhanced dose atorvastatin treating elderly patients after PCI can effectively reduce serum lipid, hs-CRP level and improve the anti-inflammatory action.

  【Key words】Percutaneous coronary intervention；Atorvastatin；High-sensitivity C-reactive protein