2018 年第 3 期 第 13 卷

微小RNA-135b在结直肠癌发生发展及治疗中的作用研究进展

The role of microRNA-135b in pathogenesis, development and treatment of colorectal cancer

作者：路丽娟刘明浩刘建军王瑞玲

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单位：100088北京，解放军第二炮兵总医院消化内科

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• 摘要：

• 结直肠癌的发生是一个多基因、多步骤的过程。许多已知基因(结肠腺瘤样息肉基因、磷脂酰肌醇-3-激酶基因、肉瘤基因、P53基因等)的突变都是通过微小RNA-135b（miR-135b）起作用。miR-135b能够通过调控基因的活性，参与许多基因的转录。抑制miR-135b的表达可以同时阻断多个致癌基因的突变，有望成为不引起耐药的抗癌新途径。在血液样本及粪便中筛查miR-135b，有望成为结直肠癌早期筛查的新方法。

• Colorectal cancer has a multigenic and multistep pathogenic process. Genic mutations of adenomatous polyposis coli, phosphoinositide-3-kinases, sarcoma gene and P53 mediated by microRNA-135b participate in the pathogenesis and development of colorectal cancer. MicroRNA-135b is involved in multiple signals of gene activity and transcription. Inhibition on microR-135b expression may be a novel anticancer approach. Detection of microRNA-135b in blood and fecal specimen can be a new method for early screening of colorectal cancer.