2018 年第 3 期 第 13 卷

特布他林与丙酸倍氯米松联合雾化吸入治疗哮喘急性发作期患者的临床效果

Clinical effect of terbutaline combined with beclomethasone dipropionate inhalation on acute attack of asthma

作者：周晓谢永伟

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单位：350025南京军区福州总医院呼吸内科(周晓)，胸外科(谢永伟)

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• 摘要：

• 目的    探讨特布他林与丙酸倍氯米松联合雾化治疗哮喘急性发作期患者的临床效果。方法    选择2014年9月至2016年6月南京军区福州总医院收治的180例哮喘急性发作期的患者，按照随机数字表法分为A、B、C 3组，各60例。A组采用特布他林雾化吸入治疗，B组采用丙酸倍氯米松雾化吸入治疗，C组采用特布他林联合丙酸倍氯米松雾化吸入治疗。观察3组患者临床总有效率、症状及体征消失时间、住院时间以及不良反应发生情况。结果    C组总有效率明显高于A组和B组［93.3%(56/60)比80.0%(48/60)、76.7%(46/60)］，差异均有统计学意义(均P＜0.05)，A组和B组总有效率差异无统计学意义(P＞0.05)。治疗后，C组呼吸困难消失时间、咳嗽消失时间、肺部体征消失时间以及住院时间明显短于A组和B组，差异均有统计学意义(均P＜0.05)。治疗后C组呼吸流量峰值明显高于A组和B组［(235±25)%比(219±20)%、(221±21)%］，差异均有统计学意义(均P＜0.05)。结论    特布他林联合丙酸倍氯米松雾化吸入治疗哮喘急性发作期效果明显，安全性高。

• Objective    To investigate the clinical effect of terbutaline combined with beclomethasone dipropionate inhalation on acute attack of asthma. Methods    A total of 180 patients with acute exacerbation of asthma who were admitted from September 2014 to June 2016 at Fuzhou General Hospital of Nanjing Military Command of People′s Liberation Army were randomly divided into group A, B, C, with 60 cases in each group. The group A was treated by terbutaline inhalation; the group B was treated by beclomethasone dipropionate inhalation; the group C was treated by terbutaline combined with beclomethasone dipropionate inhalation. Clinical efficiency, disappear time of symptoms and signs, hospital stay time and adverse reaction rate were analyzed. Results    The total effective rate in group C was significantly higher than that in group A and B［93.3%(56/60) vs 80.0%(48/60), 76.7%(46/60)］(P<0.05); the effective rate showed no significant difference between group A and B(P>0.05). After treatment, dyspnea disappear time, cough disappear time, pulmonary sign disappear time and hospital stay time in group C were significantly shorter than those in group A and B(P<0.05). The peak expiratory flow after treatment in group C was significantly higher than that in group A and B［(235±25)% vs (219±20)%, (221±21)%］(P<0.05). Conclusion    Terbutaline combined with beclomethasone dipropionate inhalation is safe and effective in treatment of acute asthma attack.