2018 年第 2 期 第 13 卷

信号通路抑制剂应用于多囊性肾病治疗的研究进展

作者：汪霞徐芳

英文作者：

单位：430000华中科技大学同济医学院附属武汉中心医院肾病内科

英文单位：

关键词：多囊性肾病；G蛋白通路；哺乳动物雷帕霉素靶蛋白通路；Wnt通路；环磷酸腺苷

英文关键词：

• 摘要：

• 多囊性肾病（PKD）是常见的单基因遗传性肾病，其特点是肾脏多发性囊肿不断扩张最终导致肾功能衰竭，对患者的生存造成严重影响。近年来，临床及基础研究的不断深入大大提高了我们对PKD发病机制的认识。本综述对目前已经明确的参与PKD的信号通路以及相关抑制剂在PKD治疗中应用进行概述，为寻找治疗PKD的有效方法提供基础。

• Research progress of signaling pathway inhibitors in treatment of polycystic kidney disease

  Wang Xia, Xu Fang

  Department of Nephrology, Wuhan Central Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, China

  Corresponding author: Xu Fang, Email: 756972975@qq.com

  【Abstract】Polycystic kidney disease（PKD） is a common monogenic disease characterized by expansion of multiple renal cysts that leads to renal failure, which has severe threaten to patient lives. The pathogenesis of PKD has been gradually cleared with the deepening of clinical and basic researches. This paper reviewed advances of signaling pathways and related inhibitors involved in treatment of PKD and provided basis for developing effective therapies.

  【Key words】Polycystic kidney disease;G protein pathway;Mammalian target of rapamycin pathway;Wnt pathway;Cyclic adenosine monophosphate