2018 年第 1 期 第 13 卷

丁苯酞对急性大脑中动脉闭塞患者早期神经功能的影响

作者：刘炫君杨国帅林海丽胡裕洁周艳辉程启慧林祝心周律

英文作者：

单位：570208中南大学湘雅医学院附属海口医院神经内科

英文单位：

关键词：急性大脑中动脉闭塞；丁苯酞；神经功能

英文关键词：

• 摘要：

• 【摘要】目的    探讨丁苯酞对急性大脑中动脉闭塞患者早期神经功能的影响。方法    选取2015年 3月至2017年3月在中南大学湘雅医学院附属海口医院住院治疗的急性大脑中动脉闭塞患者69例，采用随机数字表法将入选患者分为对照组（35例）和丁苯酞组（34例）。2组患者均进行常规治疗，丁苯酞组患者在常规治疗基础上加服丁苯酞胶囊，0.2 g/次，3次/d，连用14 d。分别于治疗前及治疗14 d后记录2组的美国国立卫生研究院卒中量表（NIHSS）评分，并通过经颅多普勒评估侧支循环代偿情况，记录治疗14 d时病死率，随访90 d后记录改良Rankin量表（mRS）评分。结果    随访90 d后最终对照组和丁苯酞组各30例纳入分析。治疗14 d时，丁苯酞组NIHSS评分明显低于治疗前和对照组［（7.9±1.3）分比（11.5±1.3）、（9.6±1.7）分］，侧支循环代偿较治疗前和对照组明显增加，差异均有统计学意义（均P＜0.05）。2组治疗14 d时病死率差异无统计学意义（P＞0.05）。丁苯酞组随访90 d时mRS评分明显低于对照组［（3.3±0.7）分比（4.3±0.6）分］，差异有统计学意义（P＜0.05）。结论    急性大脑中动脉闭塞患者早期服用丁苯酞，可改善患者的早期神经功能。

• Effect of dl-3n-butyphthalide on early neurological function in patients with acute middle cerebral occlusion

  Liu Xuanjun, Yang Guoshuai, Lin Haili, Hu Yujie, Zhou Yanhui, Cheng Qihui, Lin Zhuxin, Zhou Lü

  Department of Neurology, Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University, Haikou 570208, China

  Corresponding author: Yang Guoshuai, Email: youngester4213@sina.com

  【Abstract】Objective     To investigate the effect of dl-3n-butyphthalide(NBP) on early neurological function in patients with middle cerebral artery occlusion(MCAO). Methods    Sixty-nine patients with acute MCAO were enrolled from March 2015 to March 2017 in Affiliated Haikou Hospital of Xiangya School of Medicine, Central South University; they were randomly divided into control group（35 cases） and NBP group（34 cases）. Both groups had routine treatment for MCAO and the NBP group took NBP capsules 0.2 g/time, 3 times/d for 14 d. Score of the National Institutes of Health Stroke Scale（NIHSS） was recorded before and 14 d after treatment; cerebral collateral circulation was assessed by transcranial Doppler; the 14 d mortality was calculated; score of the modified Rankin Scale（mRS） was recorded after 90 d follow-up. Results    Finally 30 cases in control group and 30 cases in NBP group were analyzed. The NIHSS score in NBP group 14 d after treatment was significantly lower than that before treatment and that in control group［（7.9±1.3）points vs （11.5±1.3）,（9.6±1.7）points］; cerebral collateral circulation 14 d after treatment in NBP group significantly increased than that before treatment and that in control group（P＜0.05）. The 14 d mortality rate had no significant difference between groups（P＞0.05）. The 90 d mRS score in NBP group was significantly lower than that in control group(P＜0.05). Conclusion    Early administration of NBP can help improve neurological function in patients with acute MCAO.

  【Key words】Acute middle cerebral artery occlusion;Dl-3n-butyphthalide;Neurological function

  【Fund program】Natural Science Foundation of Hainan Province（20158272）; Key Science and Technology Project of Haikou（2014-073）