2018 年第 1 期 第 13 卷

血浆和肽素水平与急性冠状动脉综合征患者经皮冠状动脉介入术后不良事件的相关性

作者：彭瑞君梁茜杨希立

英文作者：

单位：528000广东省佛山市第一人民医院(中山大学附属佛山医院)心血管内科

英文单位：

关键词：急性冠状动脉综合征；和肽素；经皮冠状动脉介入

英文关键词：

• 摘要：

• 【摘要】目的    探讨血浆和肽素水平与急性冠状动脉综合征（ACS）患者经皮冠状动脉介入（PCI）术后不良事件的相关性。方法    选取广东省佛山市第一人民医院心血管内科2015年7月至2016年7月收治的拟行PCI手术治疗的188例ACS住院患者作为研究对象，入院后取肘静脉血测定和肽素水平，根据和肽素四分位数进行分组：Q1组（13.00～16.00 pmol/L）31例、Q2组（17.00～19.00 pmol/L）52例、Q3组（20.00～22.00 pmol/L）70例、Q4组（23.00～25.00 pmol/L）35例。随访12个月记录不良事件发生情况。结果    188例患者中发生不良终点事件15例（8.0%），未发生终点事件173例（92.0%）。对患者基本情况的分析结果显示，高血压、糖尿病、吸烟与终点事件的发生明显相关（P＜0.05）。对患者手术相关情况的分析结果显示，手术时间、支架置入数量、纽约心脏病协会心功能分级对终点事件的发生有明显影响（P＜0.05）。Q4组终点事件发生率明显高于Q1、Q2、Q3组［25.7%（9/35）比3.2%（1/31）、1.9%（1/52）、5.7%（4/70）］（P＜0.05）。结论    ACS患者PCI术后终点事件的发生与患者基础疾病、手术过程关联密切。血浆和肽素水平越高，终点事件的发生率相对越高。

• Relation between copeptin and adverse events after percutaneous coronary intervention in patients with acute coronary syndrome

  Peng Ruijun, Liang Xi, Yang Xili

  Department of Cardiovascular Medicine, Foshan First People′s Hospital（Foshan Hospital Affiliated to Sun Yat-sen University）, Guangdong Province, Foshan 528000, China

  Corresponding author: Peng Ruijun, Email: ctpz31@163.com

  【Abstract】Objective     To investigate the relation between copeptin and adverse events after percutaneous coronary intervention（PCI） in patients with acute coronary syndrome（ACS）. Methods    A total of 188 patients with ACS undergoing PCI from July 2015 to July 2016 in Foshan First People′s Hospital, Guangdong Province were enrolled. Plasma level of copeptin was tested after admission and the patients were divided into 4 groups according to the quartiles of copeptin level: Q1 group（13.00-16.00 pmol/L, 31 cases）, Q2 group（17.00-19.00 pmol/L, 52 cases）, Q3 group（20.00-22.00 pmol/L, 70 cases）, Q4 group（23.00-25.00 pmol/L, 35 cases）. Adverse events were recorded in 12 months follow-up. Results    Adverse endpoint events occurred in 15 patients（8.0%）; 173 patients had no endpoint events. Hypertension, diabetes and smoking were significantly related to the occurrence of endpoint events（P＜0.05）. Length of operation, number of stents and grade of heart function had significant influences on the occurrence of endpoint events（P＜0.05）. Incidence of endpoint events in Q4 group was significantly higher than that in Q1, Q2, Q3 group［25.7%（9/31） vs 3.2%（1/35）, 1.9%（1/70）, 5.7%（4/52）］（P＜0.05）. Conclusions    Basic diseases and surgical procedure are closely related to the occurrence of endpoint events in ACS patients after PCI. Incidence of endpoint events increases with the level of plasma copeptin.

  【Key words】Acute coronary syndrome;Copeptin;Percutaneous coronary intervention

  【Fund program】Self-financing Science and Technology Project of Foshan City, Guangdong Province（2015AB00310）