2017 年第 10 期 第 12 卷

心外膜脂肪组织与心房颤动关系的研究进展

Research progress on relation between epicardial adipose tissue and atrial fibrillation

作者：张福庄王国宏

英文作者：Zhang Fuzhuang Wang Guohong

单位：100176首都医科大学附属北京同仁医院心血管中心

英文单位：Cardiovascular Center Beijing Tongren Hospital Capital Medical University Beijing 100176 China

关键词：心房颤动；肥胖症；心外膜脂肪组织；炎症

英文关键词：Atrialfibrillation;Obesity;Epicardialadiposetissue;Inflammation

• 摘要：

• 心房颤动是临床较常见的心律失常，其发病率逐年增加。肥胖是心房颤动发生发展的重要危险因素，但肥胖参与心房颤动发生发展的具体机制尚不清晰。另外，心外膜脂肪组织（EAT）含量增多与心房颤动发展和维持密切相关，可能通过局部物理、神经、内分泌等作用影响心房颤动发生发展，并影响心房颤动射频导管消融术预后，逐渐成为研究心房颤动防治的新靶点。本文就EAT概述、EAT参与心房颤动发生发展的可能机制、EAT的定量及其对心房颤动射频导管消融术预后的影响进行综述，为进一步研究EAT与心房颤动关系提供依据。

• The incidence of atrial fibrillation is increasing with years; obesity has become an important risk factor of pathogenesis and development of atrial fibrillation; the mechanisms are still under investigation. Recent studies proved a close association between epicardial fat content and atrial fibrillation through local physical, neural and endocrine function; epicardial adipose tissue（EAT） may affect prognosis of catheter ablation of atrial fibrillation. This article reviewed the role of EAT involved in occurrence development, prevention and treatment of atrial fibrillation, providing basis for further research on the relation between EAT and atrial fibrillation.