2017 年第 10 期 第 12 卷

盆底功能障碍性疾病患者血浆晚期糖基化终末产物与子宫组织雌激素受体水平的相关性

Relevance between advanced glycation end products and estrogen receptor in patients with pelvic floor dysfunction

作者：陈红香虞海荣古丽加娜提王琳王芬韩涛白生宾

英文作者：Chen Hongxiang Yu Hairong Gulijianati Wang Lin Wang Fen Han Tao Bai Shengbin

单位：830001乌鲁木齐，新疆维吾尔自治区人民医院妇科（陈红香、虞海荣、古丽加娜提、王琳、王芬、韩涛）；830011乌鲁木齐，新疆医科大学基础医学院（白生宾）

英文单位：Department of Gynecology People′s Hospital of Xinjiang Uygur Autonomous Region Urumqi 830001 China（Chen HX Yu HR Gulijianati Wang L Wang F Han T）; Preclinical Medical College Xinjiang Medical University Urumqi 830011 China（Bai SB）

关键词：盆底功能障碍性疾病；血浆晚期糖基化终末产物；雌激素受体

英文关键词：Pelvicfloordysfunction;Advancedglycationendproducts;Estrogenreceptor

• 摘要：

• 目的 分析盆底功能障碍性疾病（PFD）患者血浆晚期糖基化终末产物（AGEs）和雌激素受体(ER)水平的相关性。方法 选取2015年1月至2016年10月新疆维吾尔自治区人民医院收治的32例PFD患者（观察组）和32例无PFD妇科良性疾病患者（对照组），均行子宫全切术，分别检测2组患者的血浆AGEs、子宫主韧带组织ER-α和ER-β表达水平并分析AGEs与ER的相关性。结果 观察组血浆AGEs水平明显高于对照组［(36.2±2.2)mg/L比(26.3±2.0)mg/L］（P＜0.05）。观察组ER-α表达水平明显高于对照组［(29±6)%比(19±9)%］（P＜0.05）；观察组ER-β表达水平与对照组差异无统计学意义［(13±4)%比(9±5)%］（P＞0.05），但观察组与对照组ER-β阳性率分别为56.6%、16.0%，差异有统计学意义（P＜0.05）。Spearman秩相关检验结果显示，观察组血浆AGEs与ER-α、ER-β呈正相关(r＝0.662，P＝0.004；r＝0.611，P＝0.008)。结论 PFD患者血浆AGEs和ER表达发生明显改变，二者水平呈显著正相关。

• Objective To analyze the relevance between plasma advanced glycation end products（AGEs） and estrogen receptor（ER） in patients with pelvic floor dysfunction. Methods From January 2015 to October 2016, 32 patients with pelvic floor dysfunction（observation group） and 32 patients with benign gynecologic diseases（control group） who had total hysterectomy in People′s Hospital of Xinjiang Uygur Autonomous Region were enrolled. Levels of AGEs in plasma and ER-α, ER-β in cardinal ligament of uterus tissue were analyzed. Results The plasma level of AGEs in observation group was significantly higher than that in control group［（36.2±2.2）mg/L vs （26.3±2.0）mg/L］（P＜0.05）. The level of ER-α in observation group was significantly higher than that in control group［（29±6）% vs （19±9）%］（P＜0.05）. The level of ER-β had no significant difference between groups（P＞0.05）; but the positive rate of ER-β in observation group（56.6%） was significantly higher than that in control group（16.0%）（P＜0.05）. Spearman analysis showed positive correlations of plasma AGEs level with ER-α（r＝0.662, P＝0.004） and ER-β（r＝0.611, P＝0.008）. Conclusion The level of AGEs in plasma is positively correlated with the level of ER in cardinal ligament of uterus in patients with pelvic floor dysfunction.