2017 年第 12 期 第 12 卷

转录因子Snail在肺纤维化中作用的研究进展

作者：潘伟黄敏聪徐志伟郑高利

英文作者：

单位：310000杭州，浙江省医学科学院安全性评价研究中心

英文单位：

关键词：肺纤维化；Snail；上皮间质转型；细胞凋亡；巨噬细胞

英文关键词：

• 摘要：

• 肺纤维化是一种致死率很高的疾病，至今发病机制不完全清楚。Snail在肺纤维化发展中的作用受到广泛关注。本文主要对Snail蛋白的结构及生理病理功能，及其对上皮-间质细胞转化、成纤维细胞凋亡抵抗、巨噬细胞功能的影响进行综述，以期为肺纤维化的治疗提供新的分子靶点，为肺纤维化的进一步研究提供依据。

• Research progress of transcription factor Snail in pulmonary fibrosis

  Pan Wei, Huang Mincong, Xu Zhiwei, Zheng Gaoli

  Safety Evaluation Research Center, Zhejiang Academy of Medical Sciences, Hangzhou 310000, China

  Corresponding author: Zheng Gaoli, Email: 13255810206@163.com

  【Abstract】Pulmonary fibrosis is a highly lethal disease and the pathogenesis is not completely clear. The role of the Snail in occurrence and development of pulmonary fibrosis is recognized. This review summarized structure and function of Snail protein and its influence on epithelial to mesenchymal transition, fibroblast resistance to apoptosis and function of macrophages. The Snail may be a new molecular target in treatment of pulmonary fibrosis.

  【Key words】Pulmonary fibrosis;Snail;Epithelial to mesenchymal transition;Apoptosis;Macrophages

  【Fund program】Science and Technology Project of Zhejiang Province（2016F10007）