2017 年第 10 期 第 12 卷

胺碘酮联合稳心颗粒治疗冠状动脉粥样硬化性心脏病合并频发室性期前收缩患者的临床效果

Clinical efficacy of amiodarone combined with Wenxin granules in treatment of coronary heart disease complicated with frequent ventricular premature beats

作者：靳二冬乔尚曹旭东高雯

英文作者：Jin Erdong Qiao Shang Cao Xudong Gao Wen

单位：015000内蒙古自治区巴彦淖尔市医院急诊科

英文单位：Department of Emergency Bayan Nur Hospital Inner Mongolia Autonomous Region Bayan Nur 015000 China

关键词：冠状动脉粥样硬化性心脏病；频发室性期前收缩；胺碘酮；稳心颗粒

英文关键词：Coronaryatheroscleroticheartdisease;Frequentventricularprematurebeats;Amiodarone;Wenxingranules

• 摘要：

• 目的 观察胺碘酮联合稳心颗粒治疗冠状动脉粥样硬化性心脏病（冠心病）合并频发室性期前收缩患者的临床效果。方法 选取2015年1月至2017年1月来内蒙古自治区巴彦淖尔市医院接受治疗的102例被诊断为冠心病合并频发室性期前收缩患者作为研究对象。按照随机数字表法分为观察组和对照组，各51例。其中对照组给予胺碘酮治疗；观察组在对照组的基础上联合稳心颗粒治疗，观察2组患者治疗前后临床症状及心电图改善情况、心脏代谢及功能指标变化情况、不良反应发生情况。结果 观察组症状、心电图改善显效率和总有效率高于对照组［症状改善：56.9%（29/51）比37.2%（19/51）、92.2%（47/51）比76.5%（39/51），心电图改善：51.0%（26/51）比31.4%（16/51）、90.2%（46/51）比74.5%（38/51）］，差异均有统计学意义（均P＜0.05）。治疗后观察组患者心率明显低于，房性期前收缩、室性期前收缩及心绞痛发作次数均明显少于对照组，差异均有统计学意义（均P＜0.05）。治疗后观察组患者脑钠肽、静息心率及左心室射血分数明显低于对照组，QT间期明显长于对照组，差异均有统计学意义（均P＜0.05）。2组患者总不良反应发生率差异无统计学意义(P＞0.05)。结论 胺碘酮联合稳心颗粒治疗冠心病合并频发室性期前收缩患者临床效果良好。

• Objective To observe the clinical effect of amiodarone combined with Wenxin granules on coronary heart disease complicated with frequent ventricular premature beats. Methods Totally 102 patients diagnosed of coronary heart disease complicated with frequent ventricular premature beats from January 2015 to January 2017 in Bayan Nur Hospital in Inner Mongolia Autonomous Region were randomly divided into observation group（51 cases） and control group（51 cases）. The control group was treated with amiodarone; the observation group was treated with amiodarone combined with Wenxin granules. Changes of cinical symptoms, electrocardiogram parameters, cardiac metabolism and function indexes and adverse reactions were analyzed. Results The obvious effective rate and total effective rate of clinical symptoms and electrocardiogram in observation group were significantly higher than those in control group［clinical symptoms: 56.9%（29/51） vs 37.2%（19/51）, 92.2%（47/51） vs 76.5%（39/51）; electrocardiogram: 51.0%（26/51） vs 31.4%（16/51）, 90.2%（46/51） vs 74.5%（38/51）］（P＜0.05）. After treatment, heart rate in observation group was significantly lower than that in control group; frequencies of premature atrial contraction, premature ventricular contraction and angina pectoris in observation group were significantly less than those in control group; brain natriuretic peptide level, resting heart rate and left ventricular ejection fraction in observation group were significantly lower than those in control group; the QT interval in observation group was significantly longer than that in control group（P＜0.05）. There was no significant difference of adverse reactions between groups（P＞0.05）. Conclusion Amiodarone combined with Wenxin granules is effective in treating coronary heart disease complicated with frequent ventricular premature beats.